Clozapine and D1/D2 Antagonism in Extrapyramidal Functions
Clozapine and D1/D2 Antagonism in Extrapyramidal Functions
复制标题
氯氮平和 D1/D2 锥体外系功能的拮抗作用
DOI：
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发表时间：
1992
影响因子：
10.5
通讯作者：
L. Hansen
中科院分区：
文献类型：
--
作者：
J. Gerlach;L. Hansen
氯氮平的主要优点之一是它很少产生锥体外系综合征和迟发性运动障碍。这一优势与氯氮平的非典型生化特征有关，尤其是其对D1和D2受体的联合和低阻滞作用。D2受体阻滞剂的水平太低而不能诱导锥体外系副作用，并且D1拮抗剂具有比传统D2神经阻滞剂更低的锥体外系副作用潜力，特别是关于肌张力障碍。组合和平衡的D1/D2受体阻断剂可以防止D1/D2受体功能之间的失衡（有利于D1）的发展，否则可能导致迟发性运动障碍。
One of the main advantages of clozapine is that it rarely produces extrapyramidal syndromes and tardive dyskinesia. This advantage is linked to the atypical biochemical profile of clozapine, especially its combined and low blockade of D1 and D2 receptors. The level of D2 receptor blockade is too low to induce extrapyramidal side-effects, and D1 antagonists have a lower extrapyramidal side-effect potential than traditional D2 neuroleptics, especially with respect to dystonia. The combined and balanced D1/D2 receptor blockade may prevent the development of a dysbalance between D1/D2 receptor function (in favour of D1) which otherwise might lead to tardive dyskinesia.
未接触过药物的猴子体内的多巴胺 D1 (SCH 23390) 和 D2（氟哌啶醇）拮抗剂。
影响因子：
3.4
作者：
Casey,DE
通讯作者：
Casey,DE