Tailoring tissue engineering scaffolds using electrostatic processing techniques: A study of poly(glycolic acid) electrospinning
Tailoring tissue engineering scaffolds using electrostatic processing techniques: A study of poly(glycolic acid) electrospinning
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DOI：
10.1081/ma-100108380
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发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
Bowlin, GL
中科院分区：
文献类型：
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作者：
Boland, ED;Wnek, GE;Bowlin, GL
聚乙醇酸（PGA）长期以来一直是组织工程领域流行的聚合物。 PGA 具有许多良好的特性，如生物相容性、生物吸收性和拉伸强度。传统的熔体挤出和冷拉伸纤维形成技术一般局限于直径10-12μm的纤维。静电纺丝是生产直径小得多的纤维的一种有吸引力的方法，这些纤维可作为组织工程支架。我们证明了控制 PGA 纤维直径作为溶液浓度和纤维取向的函数的能力，并显示了单轴模型中 PGA 的纤维取向、弹性模量和失效应变之间的相关性。
Poly(glycolic acid) (PGA) has long been a popular polymer in the tissue engineering field. PGA possesses many favorable properties such as biocompatibility, bioabsorbability, and tensile strength. The traditional fiber formation techniques of melt extrusion and cold-drawing are generally limited to fibers of 10-12 mum in diameter. Electrostatic spinning, or electrospinning, is an attractive approach for the production of much smaller diameter fibers which are of interest as tissue engineering scaffolds. We demonstrate the ability to control the fiber diameter of PGA as a function of solution concentration and fiber orientation, as well as show a correlation between the fiber orientation, elastic modulu, and strain to failure of PGA in a uniaxial model.