Vascular Abnormalities, Paraoxonase Activity, and Dysfunctional HDL in Primary Antiphospholipid Syndrome
Vascular Abnormalities, Paraoxonase Activity, and Dysfunctional HDL in Primary Antiphospholipid Syndrome
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DOI：
10.1001/jama.2009.1346
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发表时间：
2009-09-16
影响因子：
120.7
通讯作者：
Deanfield, John E.
中科院分区：
文献类型：
--
作者：
Charakida, Marietta;Besler, Christian;Deanfield, John E.
背景抗磷脂综合征中加速的动脉粥样硬化已被描述，但血管异常和潜在的机制仍不清楚。目的比较抗磷脂抗体（aPL）阳性患者与对照组的血管结构和功能，并评估其与对氧磷酶活性的关系。一项对来自伦敦狼疮门诊的77名抗磷脂抗体阳性的妇女进行的横断面研究，2006年6月至2009年4月期间，英格兰（90%的合格人群）和77名对照组在年龄和心血管危险因素的频率基础上匹配。测量所有患者的颈动脉内膜中层厚度（CIMT）、血流介导的扩张、脉搏波速度和对氧磷酶活性。检测高密度脂蛋白（HDL）的抗炎和抗氧化特性。主要指标CIMT、脉搏波速度、血流介导的扩张和对氧磷酶。结果aPL女性患者的CIMT和脉搏波速度均高于对照组（平均值[SD]，0.75 [0.16] vs 0.64 [0.09] mm; 95%可信区间[CI]，-0.14至-0.06; P < 0.05）。
Context Accelerated atherosclerosis has been described in antiphospholipid syndrome, but the vascular abnormalities and the underlying mechanisms remain unclear.Objectives To compare vascular structure and function in patients with positive antiphospholipid antibodies (aPL) with controls and to assess their relationship with paraoxonase activity.Design, Setting, and Participants A cross-sectional study of 77 women with positive antiphospholipid antibodies from a lupus outpatient clinic in London, England (90% of the eligible population) and 77 controls matched on frequency basis for age and cardiovascular risk factors between June 2006 and April 2009. Carotid intima media thickness (CIMT), flow-mediated dilatation, pulse wave velocity, and paraoxonase activity were measured in all patients. Anti-inflammatory and antioxidant properties of high-density lipoprotein (HDL) were examined.Main Outcome Measures CIMT, pulse wave velocity, flow-mediated dilatation, and paraoxonase.Results Women with aPL had greater CIMT and pulse wave velocity compared with controls (mean [SD], 0.75 [0.16] vs 0.64 [0.09] mm; 95% confidence interval [CI],-0.14 to-0.06; P