Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care:: a multicentre, randomized, double-blind, controlled trial
Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care:: a multicentre, randomized, double-blind, controlled trial
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DOI：
10.1111/j.1365-2036.2007.03362.x
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发表时间：
2007-08-01
影响因子：
7.6
通讯作者：
Matuchansky, C.
中科院分区：
文献类型：
--
作者：
Guyonnet, D.;Chassany, O.;Matuchansky, C.
背景健康相关生活质量（HRQoL）很少被作为评价益生菌对肠易激综合征（IBS）的作用的主要终点。方法将总共274名患有便秘为主的IBS（罗马II）的初级保健成人随机分为食用试验发酵乳或热处理酸奶（对照）6周。HRQoL和消化道症状进行了评估后3周和6周的意向治疗人口的267 subjects.Results的HRQoL不适评分，主要终点，改善（P < 0.001）在两组在第3周和第6周。HRQoL不适评分的应答率更高（65.2 vs. 47.7%，P < 0.005），腹胀评分降低[0.56 +/-（s.d.）1.01 vs. 0.31 +/- 0.87，P = 0.03]，第3周时试验组与对照组。在< 3次大便/周的受试者中，测试组与对照组相比，6周内大便频率增加（P < 0.001）。结论本研究表明益生菌食品对便秘型IBS患者的不适HRQoL评分和腹胀以及< 3次大便/周的受试者的大便频率具有有益作用。
Background Health-related quality of life (HRQoL) has been rarely evaluated as a primary endpoint in the assessment of the effect of probiotics on the irritable bowel syndrome (IBS).AimTo study the effects of fermented milk containing Bifidobacterium animalis DN-173 010 and yoghurt strains on the IBS in a multicentre, double-blind, controlled trial.Methods A total of 274 primary care adults with constipation-predominant IBS (Rome II) were randomized to consume for 6 weeks either the test fermented milk or a heat-treated yoghurt (control). HRQoL and digestive symptoms were assessed after 3 and 6 weeks on an intention-to-treat population of 267 subjects.Results The HRQoL discomfort score, the primary endpoint, improved (P < 0.001) in both groups at weeks 3 and 6. The responder rate for the HRQoL discomfort score was higher (65.2 vs. 47.7%, P < 0.005), as was the decrease in bloating score [0.56 +/- (s.d.)1.01 vs. 0.31 +/- 0.87, P = 0.03], at week 3 in the test vs. the control group. In those subjects with < 3 stools/week, stool frequency increased (P < 0.001) over 6 weeks in the test vs. control group.Conclusions This study suggests a beneficial effect of a probiotic food on discomfort HRQoL score and bloating in constipation-predominant IBS, and on stool frequency in subjects with < 3 stools/week.