The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study.
The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study.
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DOI：
10.18632/aging.202557
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发表时间：
2021-02-26
期刊：
影响因子：
--
通讯作者：
Gong S
中科院分区：
文献类型：
--
作者：
Gao D;Xu M;Wang G;Lv J;Ma X;Guo Y;Zhang D;Yang H;Jiang W;Deng F;Xia G;Lu Z;Lv L;Gong S
背景：炎症反应是2019冠状病毒病患者，特别是重症危重症患者急性呼吸窘迫综合征和多器官衰竭的主要原因。几项研究表明，高剂量维生素C可减少与败血症和急性呼吸窘迫综合征相关的炎症反应。本研究旨在确定高剂量维生素C在2019冠状病毒病中的疗效和安全性。方法：选取76例2019冠状病毒病患者，分为高剂量维生素C组（第一天每12小时静脉输注6g，随后4天1次静脉输注6g， n=46）和标准治疗组（单独标准治疗，n=30）。结果：与标准治疗组相比，高剂量维生素C组28天死亡风险降低（HR=0.14, 95% CI, 0.03-0.72）。高剂量维生素C比标准治疗更能改善氧支持状态（63.9% vs 36.1%）。没有与高剂量维生素C治疗相关的安全事件。结论：大剂量维生素C可降低2019冠状病毒病患者死亡率，改善氧支持状态，无不良事件发生。
Background: The inflammatory reaction is the main cause of acute respiratory distress syndrome and multiple organ failure in patients with Coronavirus disease 2019, especially those with severe and critical illness. Several studies suggested that high-dose vitamin C reduced inflammatory reaction associated with sepsis and acute respiratory distress syndrome. This study aimed to determine the efficacy and safety of high-dose vitamin C in Coronavirus disease 2019. Methods: We included 76 patients with Coronavirus disease 2019, classified into the high-dose vitamin C group (loading dose of 6g intravenous infusion per 12 hr on the first day, and 6g once for the following 4 days, n=46) and the standard therapy group (standard therapy alone, n=30). Results: The risk of 28-day mortality was reduced for the high-dose vitamin C versus the standard therapy group (HR=0.14, 95% CI, 0.03-0.72). Oxygen support status was improved more with high-dose vitamin C than standard therapy (63.9% vs 36.1%). No safety events were associated with high-dose vitamin C therapy. Conclusion: High-dose vitamin C may reduce the mortality and improve oxygen support status in patients with Coronavirus disease 2019 without adverse events.
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