A molecular portrait of Arabidopsis meiosis.
A molecular portrait of Arabidopsis meiosis.
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DOI：
10.1199/tab.0095
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发表时间：
2006-01-01
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影响因子：
--
通讯作者：
Ma, Hong
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文献类型：
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作者：
Ma, Hong
未标记：减数分裂对真核有性繁殖是必不可少的，对个体间的遗传多样性也很重要。在过去的十年里，在拟南芥中所做的努力极大地扩展了我们对植物减数分裂的分子基础的理解，这传统上提供了关于减数分裂的细胞学描述的许多信息。通过对生育力降低的突变体的正向遗传分析和对已知减数分裂基因同源基因的反向遗传研究，我们现在对减数分裂重组的重要基因及其与配对和联会的关系有了基本的了解，这是确保适当的同源分离的关键过程。此外，一些影响减数分裂进程、纺锤体组装、染色体分离和减数分裂胞质分裂的基因也已被发现和鉴定。值得注意的是，拟南芥的分子遗传学研究也揭示了真核生物中尚未被其他地方认识到的减数分裂秘密，包括可能是植物独有的基因功能，以及那些可能与动物和真菌共享的基因功能。随着我们进入植物生物学的后基因组学时代，毫无疑问，在植物发育和细胞生物学这一重要领域，未来十年将会有更多的发现。摘要：DAPI，4‘，6-二氨基-2-苯基吲哚；DSB，双链断裂；DSBR，双链断裂修复；SC，联会复合体；透射电子显微镜。
UNLABELLED: Meiosis is essential for eukaryotic sexual reproduction and important for genetic diversity among individuals. Efforts during the last decade in Arabidopsis have greatly expanded our understanding of the molecular basis of plant meiosis, which has traditionally provided much information about the cytological description of meiosis. Through both forward genetic analysis of mutants with reduced fertility and reverse genetic studies of homologs of known meiotic genes, we now have a basic knowledge about genes important for meiotic recombination and its relationship to pairing and synapsis, critical processes that ensure proper homolog segregation. In addition, several genes affecting meiotic progression, spindle assembly, chromosome separation, and meiotic cytokinesis have also been uncovered and characterized. It is worth noting that Arabidopsis molecular genetic studies are also revealing secrets of meiosis that have not yet been recognized elsewhere among eukaryotes, including gene functions that might be unique to plants and those that are potentially shared with animals and fungi. As we enter the post-genomics era of plant biology, there is no doubt that the next ten years will see an even greater number of discoveries in this important area of plant development and cell biology.ABBREVIATIONS: DAPI, 4',6-diamidino-2-phenylindole; DSB, double strand break; DSBR, double strand break repair; SC, synaptonemal complex; TEM, transmission electron microscopy.