Homeobox genes and connective tissue patterning.
Homeobox genes and connective tissue patterning.
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DOI：
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发表时间：
1995-03
期刊：
影响因子：
4.6
通讯作者：
Guillermo Oliver;Roland Wehr;N. Jenkins;N. Copeland;B. Cheyette;V. Hartenstein;S. Zipursky;Peter Gruss
中科院分区：
文献类型：
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作者：
Guillermo Oliver;Roland Wehr;N. Jenkins;N. Copeland;B. Cheyette;V. Hartenstein;S. Zipursky;Peter Gruss
在脊椎动物中，肢体肌腱来源于在发育早期从侧板中胚层迁移过来的细胞。虽然一些导致这些组织形成的发育步骤是已知的，但对控制它们的分子机制知之甚少。我们已经确定了两个小鼠同源盒基因，Six 1和Six 2，它们在肢体肌腱发育过程中以互补的方式表达。这两个基因的转录本在不同组的指骨肌腱中被发现。61和62也分别在骨骼肌和平滑肌中表达。这些基因可能通过沿肢轴设置位置值参与肢体指骨远端肌腱的模式。
In vertebrates, limb tendons are derived from cells that migrate from the lateral plate mesoderm during early development. While some of the developmental steps leading to the formation of these tissues are known, little is known about the molecular mechanisms controlling them. We have identified two murine homeobox-containing genes, Six 1 and Six 2, which are expressed in a complementary fashion during the development of limb tendons. Transcripts for both genes are found in different sets of phalangeal tendons. Six 1 and Six 2 also are expressed in skeletal and smooth muscle, respectively. These genes may participate in the patterning of the distal tendons of the limb phalanges by setting positional values along the limb axes.