The yeast prion protein Ure2: insights into the mechanism of amyloid formation
The yeast prion protein Ure2: insights into the mechanism of amyloid formation
复制标题
酵母朊病毒蛋白 Ure2：深入了解淀粉样蛋白形成机制
DOI：
10.1042/bst0391359
复制
发表时间：
2011-10-01
影响因子：
3.9
通讯作者：
Perrett, Sarah
中科院分区：
文献类型：
--
作者：
Chen, Li-Jun;Sawyer, Elizabeth B.;Perrett, Sarah
尿素2是氮代谢的调节剂，是酵母菌中[URE3]朊病毒状态的蛋白质决定因子。在转化为朊病毒形式后，Ure2经历可遗传的构象变化，变为淀粉样聚集状态并失去其调节功能。已经发现许多分子伴侣影响Ure2的朊病毒性质。在我们的实验室进行的研究已旨在阐明的结构的尿素2纤维，淀粉样蛋白形成的机制和伴侣蛋白对尿素2纤维形成的影响。
Ure2, a regulator of nitrogen metabolism, is the protein determinant of the [URE3] prion state in Saccharomyces cerevisioe. Upon conversion into the prion form, Ure2 undergoes a heritable conformational change to an amyloid-like aggregated state and loses its regulatory function. A number of molecular chaperones have been found to affect the prion properties of Ure2. The studies carried out in our laboratory have been aimed at elucidating the structure of Ure2 fibrils, the mechanism of amyloid formation and the effect of chaperones on the fibril formation of Ure2.