Insulin-like growth factor 1 reduces age-related disorders induced by prenatal stress in female rats
Insulin-like growth factor 1 reduces age-related disorders induced by prenatal stress in female rats
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DOI：
10.1016/j.neurobiolaging.2005.01.008
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发表时间：
2006-01-01
影响因子：
4.2
通讯作者：
Garcia-Segura, LM
中科院分区：
文献类型：
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作者：
Darnaudéry, M;Perez-Martin, M;Garcia-Segura, LM
产前应激可诱发成人生活中的永久性异常，如焦虑样行为的增加和下丘脑-垂体-肾上腺轴系统的过度活跃。本研究旨在探讨产前应激是否会诱发老年雌性大鼠空间学习障碍。此外，由于最近有报道称胰岛素样生长因子1 （IGF-1）可减轻老年大鼠的空间学习缺陷并促进海马神经发生，我们评估了慢性输注IGF-1对年龄相关疾病的影响。我们的研究结果表明，在产前生活中受到压力的雌性在水迷宫任务中表现出学习障碍。慢性IGF-1治疗可恢复其空间能力，减少HPA轴功能障碍，提高血浆雌二醇水平。与这些作用平行的是，慢性IGF-1上调海马齿状回的神经增殖。这些发现支持了衰老过程中某些神经系统疾病易感性的早期编程假设，并加强了IGF-1在脑衰老过程中的潜在治疗价值。(C) 2005爱思唯尔公司版权所有。
Stress during the prenatal period can induce permanent abnormalities in adult life such as increased anxiety-like behavior and hyperactivity of hypothalamo-pituitary-adrenal (HPA) axis system. The present study was designed to investigate whether prenatal stress could induce spatial learning impairment in aged female rats. Furthermore, since it has been recently reported that insulin-like growth factor 1 (IGF-1) attenuates spatial learning deficits in aged rats and promotes neurogenesis in the hippocampus, we assessed the impact of a chronic infusion of IGF-1 on age-related disorders. Our results show that females stressed during prenatal life exhibit learning impairments in the water maze task. Chronic IGF-1 treatment restores their spatial abilities, reduces their HPA axis dysfunction and increases plasma estradiol levels. Parallel to these effects, chronic IGF-1 up-regulates neural proliferation in the dentate gyrus of the hippocampus. These findings support the hypothesis of an early programming of the vulnerability to some neurological diseases during senescence and reinforce the potential therapeutic interest of IGF-1 during brain aging. (C) 2005 Elsevier Inc. All rights reserved.