THE MHC HAPLOTYPES OF THE CHICKEN
THE MHC HAPLOTYPES OF THE CHICKEN
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DOI：
10.1007/bf00372021
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发表时间：
1982-01-01
期刊：
影响因子：
3.2
通讯作者：
HALA, K
中科院分区：
文献类型：
--
作者：
SIMONSEN, M;CRONE, M;HALA, K
G.鸡是B复合体，其中3类细胞膜抗原已通过血清学、组织遗传学和生物化学方法明确界定。其中两类与哺乳动物的I类和II类同源（分别为B-F和B-L），而第三类（B-G）是红系细胞系的分化抗原;该类的哺乳动物同源物仍不确定。所述B单倍型包含每类至少1个显示显著强度的连锁不平衡的基因。首次系统比较血清学和组织发生学方法的等位基因产物（allomorphs）的15个单倍型，包括所有的11个被接受为标准的B单倍型在最近的国际研讨会上鸡MHC在奥地利因斯布鲁克。分析显示了许多相似之处，但只有4对可能的身份：G2和G12，F4和F13，L4和L13，L12和L19。B-G基因座的多态性程度显然与I类（B-F）基因座相当。标准的单倍型几乎都是白色来航鸡的衍生，其他鸡种和野生鸡的初步分型表明存在着更广泛的异型。
The major histocompatibility complex (MHC) of G. gallus is the B complex of which 3 classes of cell-membrane antigens have been clearly defined by serological, histogenetic and biochemical methods. Two of these classes are homologous to classes I and II of mammals (B-F and B-L, respectively), while the 3rd (B-G) is a differentiation antigen of the erythroid cell line; the mammalian homologue of this class is still undefined. The B haplotypes comprise at least 1 gene of each class that displays linkage disequilibrium of a remarkable strength. The 1st systematic comparison by serological and histogenic methods of the allelic products (allomorphs) of 15 haplotypes, including all of the 11 that were accepted as standard B haplotypes at the recent international workshop on the chicken MHC in Innsbruck, Austria is presented. The analysis has revealed many similarities, but only 4 pairs of probable identities: G2 and G12, F4 and F13, L4 and L13, L12 and L19. The B-G locus is apparently comparable in its degree of polymorphism to the class I (B-F) locus. The standard haplotypes are almost all of White Leghorn derivation, and preliminary typings of other breeds of chickens and of wild chickens indicate the existence of a much wider spectrum of allomorphs.