The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population
The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population
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在中国汉族人群中，白细胞介素 1f7 rs3811047 G>A 变异与胃贲门腺癌风险降低相关。
DOI：
10.1007/s13277-013-1463-y
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发表时间：
2014-04-01
期刊：
影响因子：
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通讯作者：
Gu, Haiyong
中科院分区：
文献类型：
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作者：
Wang, Xu;Yin, Jun;Gu, Haiyong
目的探讨白细胞介素1A（IL 1A）rs 1800587 C > T、IL 1B rs 16944 G > A、IL 1f 7 rs3811047 G > A、IL 3 rs 40401 C > T、IL 3 rs 2073506 G > A和IL 7 R alpha rs6897932 A > G等6种功能性单核苷酸多态性（SNP）与贲门腺癌（GCA）的相关性。我们进行了一项以医院为基础的病例对照研究，以评估这些SNP的遗传效应。本研究共纳入243例GCA病例和476例对照。使用定制设计的48-SNP扫描（TM）试剂盒来确定基因型。在单基因座分析或隐性遗传模型中，IL 1f 7 rs3811047 G > A多态性与GCA风险降低显著相关。然而，其他5个SNPs与GCA风险之间没有显着关联。提示IL 1f 7 rs3811047 G > A多态性可能与GCA易感性有关。然而，我们的研究的统计能力是有限的，需要大型设计良好的研究和进一步的功能研究来证实我们的发现。
To investigate the association between gastric cardiac adenocarcinoma (GCA) and six functional single nucleotide polymorphisms (SNPs) including interleukin 1A (IL1A) rs1800587 C > T, IL1B rs16944 G > A, IL1f7 rs3811047 G > A, IL3 rs40401 C > T, IL3 rs2073506 G > A, and IL7R alpha rs6897932 A > G. We performed a hospital-based case-control study to evaluate the genetic effects of these SNPs. A total of 243 GCA cases and 476 controls were enrolled in this study. A custom-by-design 48-Plex SNPscan(TM) kit was used to determine the genotypes. The IL1f7 rs3811047 G > A polymorphism was significantly associated with a decreased risk of GCA either in the single locus analyses or the recessive genetic model. However, there was no significant association between the other five SNPs and GCA risk. These results elucidated that the functional polymorphism, IL1f7 rs3811047 G > A, might contribute to GCA susceptibility. However, the statistical power of our study was limited, large well-designed studies and further functional investigations are needed to confirm our findings.