Associations between Nine Polymorphisms in EXO1 and Cancer Susceptibility: A Systematic Review and Meta-Analysis of 39 Case-control Studies.
Associations between Nine Polymorphisms in EXO1 and Cancer Susceptibility: A Systematic Review and Meta-Analysis of 39 Case-control Studies.
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EXO1 的九个多态性与癌症易感性之间的关联：39 项病例对照研究的系统回顾和荟萃分析
DOI：
10.1038/srep29270
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发表时间：
2016-07-08
影响因子：
4.6
通讯作者：
Liang C
中科院分区：
文献类型：
--
作者：
Zhang M;Zhao D;Yan C;Zhang L;Liang C
越来越多的研究强调了EXO1多态性与癌症风险之间的潜在联系，尽管尚未达成共识。因此，我们的目的是通过进行荟萃分析来获得EXO1多态性和癌症易感性的全面和最新评估。在PubMed、EMbase、Web of Science和万方数据库中进行全面的文献检索。应用比值比（OR）和95%可信区间（CI）对结果进行评估。最后，涉及21，651例病例和21，348例对照的9种EXO1多态性的39项病例对照研究符合我们的纳入标准。汇总分析表明，rs1047840多态性赋予显着增加的易感性，癌症的等位基因模型。同样，rs3754093、rs1776177、rs9350、rs10802996、rs1635498、rs1776148和rs851797多态性也分别与等位基因模型中癌症易感性增加相关，而rs1635517多态性未发现显著相关性。对于rs1047840多态性，在种族亚组分析中，在所有遗传模型中确定了亚洲人和高加索人在等位基因模型中对癌症的易感性显著增加。我们的研究结果提供了证据，rs1047840，rs9350，rs10802996，rs1635498，rs1776148，rs1776177，rs3754093和rs851797多态性可能是癌症的危险因素。
An increasing number of studies have highlighted the potential link between EXO1 polymorphisms and cancer risk, although no consensus has yet been obtained. Thus, we aimed to obtain a thorough and current assessment of EXO1 polymorphisms and cancer susceptibility by performing a meta-analysis. A comprehensive literature retrieval was performed on PubMed, EMbase, Web of Science and Wanfang databases. The odds ratio (OR) and 95% confidence interval (CI) were applied to assess the results. Finally, 39 case-control studies of the nine EXO1 polymorphisms that involved 21,651 cases and 21,348 controls met our inclusion criteria. The pooled analysis indicated that the rs1047840 polymorphism conferred a significantly increased susceptibility to cancer in an allelic model. Similarly, the rs3754093, rs1776177, rs9350, rs10802996, rs1635498, rs1776148 and rs851797 polymorphisms were also associated with an increased susceptibility to cancer in an allelic model, respectively, while no significant association was identified for rs1635517 polymorphism. For the rs1047840 polymorphism, in an ethnicity subgroup analysis, a significantly increased susceptibility to cancer for Asians was identified in all the genetic models and for Caucasians in an allelic model. Our findings provide the evidence that the rs1047840, rs9350, rs10802996, rs1635498, rs1776148, rs1776177, rs3754093 and rs851797 polymorphisms may act as risk factors for cancer.