YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis.
YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis.
复制标题
DOI：
10.4049/jimmunol.1600721
复制
发表时间：
2016-09-01
期刊：
影响因子：
--
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Trabucco SE;Gerstein RM;Zhang H
生发中心（GC）反应产生高亲和力抗体，用于强大的适应性免疫应答。如果失调，同样的过程会导致GC B细胞对淋巴瘤发生敏感。重要的是要了解GC反应是如何调节的。在这项研究中，我们表明，转录因子YY1是必需的，以维持一个强大的GC反应在小鼠中。在GC反应期间，YY 1的选择性消融显著降低GC B细胞的频率和数量。GC B细胞的减少伴随着这些细胞中凋亡的增加。此外，我们发现YY 1的缺失破坏了暗区和亮区之间的平衡，导致暗区细胞的优先减少。总之，这些结果表明YY 1在调节GC暗区和亮区细胞之间的平衡以及GC B细胞的存活和死亡之间起重要作用。
The germinal center (GC) reaction produces high-affinity antibodies for a robust adaptive immune response. If dysregulated, the same processes cause GC B cells to become susceptible to lymphomagenesis. It is important to understand how the GC reaction is regulated. In this study, we show that transcription factor YY1 is required to maintain a robust GC reaction in mice. Selective ablation of YY1 significantly decreased in the frequency and number of GC B cells during the GC reaction. This decrease of GC B cells was accompanied by increased apoptosis in these cells. Further, we found that loss of YY1 disrupted the balance between dark zones and light zones, leading to a preferential decrease in dark zone cells. Collectively, these results indicate that YY1 plays an important role in regulating the balance between dark zone and light zone cells in GCs and between survival and death of GC B cells.