The Organization of the Forelimb Representation of the C57BL/6 Mouse Motor Cortex as Defined by Intracortical Microstimulation and Cytoarchitecture
The Organization of the Forelimb Representation of the C57BL/6 Mouse Motor Cortex as Defined by Intracortical Microstimulation and Cytoarchitecture
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DOI：
10.1093/cercor/bhq159
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发表时间：
2011-04-01
期刊：
影响因子：
3.7
通讯作者：
Jones, Theresa A.
中科院分区：
文献类型：
--
作者：
Tennant, Kelly A.;Adkins, DeAnna L.;Jones, Theresa A.
猴、猫和大鼠运动皮层的前肢代表区的组织已经得到了深入的研究，但其在小鼠中的表征远远落后。我们使用皮质内微刺激（ICMS）和cytoarchitectonics的特点的一般组织的C57 BL/6小鼠运动皮层，和前肢表示更详细。我们发现，前肢区域跨越额叶皮层的大面积，主要由触须，颈部，肩部和后肢代表接壤。它包括一个大的尾部前肢区，占主导地位的数字表示，和一个小的喙前肢区，包含肘部和手腕表示。当整个运动皮层被映射时，发现前肢是最大的运动表示，其次是头部和后肢表示。ICMS定义的运动皮质跨越细胞结构上确定的外侧无颗粒皮质（AG 1），也延伸到内侧无颗粒皮质。前肢和后肢的代表延伸到颗粒皮质的区域，也有AG 1的细胞结构特征，与大鼠的主要运动-体感重叠区（OL）的特点。因此，小鼠运动皮层具有同源性与大鼠在有2个前肢代表和OL，但不同的是，在优势的数字表示。
The organization of forelimb representation areas of the monkey, cat, and rat motor cortices has been studied in depth, but its characterization in the mouse lags far behind. We used intracortical microstimulation (ICMS) and cytoarchitectonics to characterize the general organization of the C57BL/6 mouse motor cortex, and the forelimb representation in more detail. We found that the forelimb region spans a large area of frontal cortex, bordered primarily by vibrissa, neck, shoulder, and hindlimb representations. It included a large caudal forelimb area, dominated by digit representation, and a small rostral forelimb area, containing elbow and wrist representations. When the entire motor cortex was mapped, the forelimb was found to be the largest movement representation, followed by head and hindlimb representations. The ICMS-defined motor cortex spanned cytoarchitecturally identified lateral agranular cortex (AGl) and also extended into medial agranular cortex. Forelimb and hindlimb representations extended into granular cortex in a region that also had cytoarchitectural characteristics of AGl, consistent with the primary motor-somatosensory overlap zone (OL) characterized in rats. Thus, the mouse motor cortex has homologies with the rat in having 2 forelimb representations and an OL but is distinct in the predominance of digit representations.