Human milk as a bioindicator for body burden of PCDDs, PCDFs, organochlorine pesticides, and PCBs.
Human milk as a bioindicator for body burden of PCDDs, PCDFs, organochlorine pesticides, and PCBs.
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DOI：
10.1289/ehp.102-1566908
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发表时间：
1994-01
影响因子：
10.4
通讯作者：
Wilmers K
中科院分区：
文献类型：
--
作者：
Fürst P;Fürst C;Wilmers K
北莱茵-威斯特法伦州食品、药物和环境化学国家实验室根据Chemisches Landesuntersuchungsamt的研究，自1984年以来，已对600多份母乳样本进行了多氯二苯并二恶英（PCDD）和多氯二苯并呋喃（PCDF）分析，并对1400多份母乳样本进行了有机氯农药（OCPs）和多氯联苯（PCB）分析。所有样本都是在自愿的基础上从大多数居住在德国联邦州北莱茵河威斯特伐利亚的哺乳母亲那里收集的。迄今为止分析的样本显示了多氯二苯并对二恶英和多氯二苯并呋喃的典型模式。在210种可能的同源物中，只有那些被2，3，7，8-氯取代的同源物被发现。虽然二氯二恶英通常显示最高的浓度，但其他二恶英同源物的含量随着氯原子数量的减少而减少。发现多氯二苯并呋喃的模式不同。在这一组中，2，3，4，7，8-P5 CDF是含量最高的同系物，其次是六氯二苯并呋喃。四氯二苯并二恶英（TCDD）的平均含量按脂肪计算为3.2皮克/克，而多氯二苯并二恶英和多氯二苯并呋喃的总含量按I-TEq计算（NATO/CMMS）按脂肪计算为29.3皮克/克。过去两年的调查显示，与前几年相比，这一数字有所下降。这可能表明，为尽量减少二恶英排放和关闭已知来源所作的努力已经对人体负担产生了影响。尽管在相当长的一段时间内已经被禁止使用，但一些亲脂性持久性农药，如滴滴涕、狄氏剂、六氯苯和六氯环己烷，仍然可以在母乳中找到。（250字处删节）
In the State Laboratory of North Rhine-Westphalia for Food, Pharmaceutical and Environmental Chemistry (Chemisches Landesuntersuchungsamt), more than 600 individual human milk samples have been analyzed for polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), and more than 1400 individual milk samples have been analyzed for organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) since 1984. All samples were collected on a voluntary basis from nursing mothers mostly living in North Rhine Westphalia, a federal state in Germany. The samples analyzed so far show a typical pattern of PCDDs and PCDFs. Out of the 210 possible congeners, only those with 2,3,7,8-chlorine substitution were found. While OCDD normally shows the highest concentration, the levels of the other dioxin congeners decrease with decreasing number of chlorine atoms. A different pattern was found for PCDFs. Within this group 2,3,4,7,8-P5CDF is the most abundant congener, followed by the hexachlorodibenzofurans. The mean level of tetrachlorodibenzodioxin (TCDD) was found to be of 3.2 pg/g on a fat basis and for total PCDDs and PCDFs, calculated as I-TEq (NATO/CMMS), 29.3 pg/g on a fat basis. The investigations of the past 2 years have revealed somewhat lower levels compared to former years. This might be an indication that the efforts undertaken to minimize dioxin emissions and to shut down known sources have already had an effect on the body burden of humans. Although mostly banned for a considerable period of time now, some lipophilic persistent pesticides such as DDT, dieldrin, hexachlorobenzene (HCB), and hexachlorocyclohexanes (HCH) can still be found in human milk.(ABSTRACT TRUNCATED AT 250 WORDS)