Effects of a time‐varying strong magnetic field on transient increase in cytosolic free Ca2+ induced by bradykinin in cultured bovine adrenal chromaffin cells
Effects of a time‐varying strong magnetic field on transient increase in cytosolic free Ca2+ induced by bradykinin in cultured bovine adrenal chromaffin cells
复制标题
时变强磁场对缓激肽诱导培养的牛肾上腺嗜铬细胞胞浆游离 Ca2+ 瞬时增加的影响
DOI：
10.1016/s0014-5793(98)01078-3
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发表时间：
1998
期刊：
影响因子：
3.5
通讯作者：
H. Miyamoto
中科院分区：
文献类型：
--
作者：
T. Ikehara;K. Park;H. Houchi;H. Yamaguchi;K. Hosokawa;M. Shono;K. Minakuchi;T. Tamaki;Y. Kinouchi;K. Yoshizaki;H. Miyamoto
我们测试了暴露于以 3 秒为间隔在 0.07 至 1.7 T 之间变化的时变磁场对牛肾上腺嗜铬细胞中缓激肽刺激的细胞内 Ca2+ 瞬时增加的影响。添加缓激肽在几分钟内诱导细胞内Ca2+增加。暴露于磁场完全抑制了无 Ca2+ 培养基中细胞内 Ca2+ 的增加。当最大磁通密度超过 1.4 T 时，抑制作用持续 15 分钟。这些结果表明，暴露抑制了细胞内 Ca2+ 储存的 Ca2+ 释放。
We tested the effects of exposure to a time‐varying magnetic field changing between 0.07 and 1.7 T at an interval of 3 s on transient increase in intracellular Ca2+stimulated by bradykinin in bovine adrenal chromaffin cells. Addition of bradykinin induced the increase in intracellular Ca2+within a few minutes. The exposure to the magnetic field perfectly suppressed the increase in intracellular Ca2+in Ca2+‐free medium. The inhibition occurred for 15 min when the maximum magnetic flux density was more than 1.4 T. These results suggest that the exposure inhibits Ca2+release from intracellular Ca2+stores.