Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood
Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood
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DOI：
10.3109/1547691x.2012.755580
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发表时间：
2013-10-01
影响因子：
3.3
通讯作者：
Nygaard, Unni C.
中科院分区：
文献类型：
--
作者：
Granum, Berit;Haug, Line S.;Nygaard, Unni C.
全氟烷基物质（PFAS）被认为具有免疫抑制作用;子宫内和生命最初几年的接触特别令人关注，因为胎儿和幼儿非常容易受到有毒物质的接触。本研究的目的是研究产前暴露于PFAS对3岁以下儿童对儿科疫苗的反应和免疫相关健康结局的影响。在前瞻性出生队列BraMat（挪威母婴队列研究（MoBa）的一个子队列）中，2007-2008年招募了来自挪威奥斯陆和阿克尔舒斯的孕妇。每年进行三次基于胰岛素的随访。在分娩时从母亲和3岁的孩子身上采集血样。作为衡量出生前接触PFAS的一项指标，测定了99名BraMat参与者母体血液中全氟辛酸盐（PFOA）、全氟壬酸盐（PFNA）、全氟己烷磺酸盐（PFHxS）和全氟辛烷磺酸盐（PFOS）的浓度。主要结果指标为3岁以下儿童的抗疫苗抗体水平、常见传染病以及过敏和哮喘相关的健康结果。3岁儿童血清中抗风疹抗体水平与4种PFAS浓度呈负相关。此外，母体PFOA和PFNA浓度与儿童普通感冒发作次数呈正相关，PFOA和PFHxS与胃肠炎发作次数呈正相关。未发现母体PFAS浓度与所调查的过敏和哮喘相关健康结果之间存在关联。结果表明，出生前暴露于PFAS可能与儿童早期的免疫抑制有关。
Perfluoroalkyl substances (PFAS) are suggested to have immunosuppressive effects; exposure in utero and in the first years of life is of special concern as fetuses and small children are highly vulnerable to toxicant exposure. The objective of this study was to investigate the effect of prenatal exposure to PFAS on responses to pediatric vaccines and immune-related health outcomes in children up to 3 years of age. In the prospective birth-cohort BraMat, a sub-cohort of the Norwegian Mother and Child Cohort Study (MoBa), pregnant women from Oslo and Akershus, Norway, were recruited during 2007-2008. Three annual questionnaire-based follow-ups were performed. Blood samples were collected from the mothers at the time of delivery and from the children at the age of 3 years. As a measure of pre-natal exposure to PFAS, the concentrations of perfluorooctanoate (PFOA), perfluorononanoate (PFNA), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS) were determined in maternal blood from 99 BraMat participants. Main outcome measures were anti-vaccine antibody levels, common infectious diseases and allergy-and asthma-related health outcomes in the children up to the age of 3 years. There was an inverse association between the level of anti-rubella antibodies in the children's serum at age 3 years and the concentrations of the four PFAS. Furthermore, there was a positive association between the maternal concentrations of PFOA and PFNA and the number of episodes of common cold for the children, and between PFOA and PFHxS and the number of episodes of gastroenteritis. No associations were found between maternal PFAS concentrations and the allergy-and asthma-related health outcomes investigated. The results indicate that pre-natal exposure to PFAS may be associated with immunosuppression in early childhood.