Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage.
Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage.
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DOI：
10.1155/2012/808934
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发表时间：
2012
影响因子：
3
通讯作者：
Boggs K
中科院分区：
文献类型：
--
作者：
Reisman D;Takahashi P;Polson A;Boggs K
p53 肿瘤抑制因子诱导基因转录，这些基因响应 DNA 损伤或其他细胞应激源而负向调节细胞周期的进展，从而参与维持基因组稳定性。大量研究表明，在细胞从 G0/G1 进入 S 期的早期 S 期之前或期间，通过两个 DNA 结合因子 RBP-Jκ 和 C/EBPβ-2 的联合作用，p53 转录被激活。在这里，我们回顾了这一诱导过程提供可用 p53 mRNA 的证据，以便为细胞在 S 期的 DNA 损伤做好准备，这确保了在退出细胞周期的这一阶段之前对 DNA 损伤的快速反应。
The p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. Numerous studies have demonstrated that p53 transcription is activated before or during early S-phase in cells progressing from G0/G1 into S-phase through the combined action of two DNA-binding factors RBP-Jκ and C/EBPβ-2. Here, we review evidence that this induction occurs to provide available p53 mRNA in order to prepare the cell for DNA damage in S-phase, this ensuring a rapid response to DNA damage before exiting this stage of the cell cycle.