Combinatorial glycosylation of glycopeptide antibiotics
Combinatorial glycosylation of glycopeptide antibiotics
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DOI：
10.1016/s1074-5521(02)00289-2
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发表时间：
2002-12-01
影响因子：
--
通讯作者：
Baltz, RH
中科院分区：
文献类型：
--
作者：
Baltz, RH
来自万古霉素产生菌的糖基转移酶GtfE和GtfD具有混杂底物和NDP-糖专一性。它们已被用来合成含有万古霉素和替考拉宁的七肽支架的新型糖肽抗生素[1]。
The glycosyltransferases GtfE and GtfD from the vancomycin producer Amycolatopsis orientalis have promiscuous substrate and NDP-sugar specificities. They have been used to generate novel glycopeptide antibiotics containing the heptapeptide scaffolds of vancomycin and teichoplanin [1].