Phase diagrams and ordering in charged membranes: Binary mixtures of charged and neutral lipids
Phase diagrams and ordering in charged membranes: Binary mixtures of charged and neutral lipids
复制标题
带电膜的相图和排序：带电和中性脂质的二元混合物
DOI：
10.1021/acs.jpcb.6b03102
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
David Andelman
中科院分区：
文献类型：
--
作者：
Naofumi Shimokawa;Hiroki Himeno;Tsutomu Hamada;Masahiro Takagi;Shigeyuki Komura;David Andelman
我们提出了一个模型描述的相行为的双组分膜组成的二元混合物的带电和中性脂质。我们考虑了烃链的结构相变（主相变），并研究了这种相变和横向相分离之间的相互作用。带电脂质的存在显着影响的多组分膜的相行为。由于脂质分子体积守恒，带电脂质的主转变温度低于中性脂质。此外，与中性脂质的二元混合物相比，带电脂质的二元混合物中的膜相分离被抑制，与最近的实验雅阁。我们区分两种类型的带电膜：带电饱和脂质/中性不饱和脂质的混合物和中性饱和脂质/带电不饱和脂质的混合物的第二种情况。相应的相行为的计算和显示是非常不同的。最后，我们讨论了盐的加入对相分离的影响和脂质分子面积的温度依赖性。
We propose a model describing the phase behavior of two-component membranes consisting of binary mixtures of electrically charged and neutral lipids. We take into account the structural phase transition (main-transition) of the hydrocarbon chains, and investigate the interplay between this phase transition and the lateral phase separation. The presence of charged lipids significantly affects the phase behavior of the multicomponent membrane. Due to the conservation of lipid molecular volume, the main-transition temperature of charged lipids is lower than that of neutral ones. Furthermore, as compared with binary mixtures of neutral lipids, the membrane phase separation in binary mixtures of charged lipids is suppressed, in accord with recent experiments. We distinguish between two types of charged membranes: mixtures of charged saturated lipid/neutral unsaturated lipid and a second case of mixtures of neutral saturated lipid/charged unsaturated lipid. The corresponding phase behavior is calculated and shown to be very different. Finally, we discuss the effect of added salt on the phase separation and the temperature dependence of the lipid molecular area.