Psychosocial vs. "physical" stress situations in rodents and humans - Role of neurotrophins
Psychosocial vs. "physical" stress situations in rodents and humans - Role of neurotrophins
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DOI：
10.1016/s0031-9384(01)00498-x
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发表时间：
2001-06-01
影响因子：
2.9
通讯作者：
Santucci, D
中科院分区：
文献类型：
--
作者：
Alleva, E;Santucci, D
神经生长因子（NGF）和脑源性神经营养因子（BDNF）是经过充分研究的多肽生长因子，参与特定外周和中枢神经元细胞群的发育和维持。除了作为神经营养剂的作用外，NGF 还控制脊椎动物生理学中非常复杂的功能。事实上，神经系统外的多种细胞都能够合成NGF，包括上皮细胞、成纤维细胞、淋巴细胞和巨噬细胞。 NGF的靶细胞已被确定为神经、免疫细胞。和内分泌系统，提示 NGF ma？；通过多种途径发挥作用，最终调节生理稳态和行为应对。我们使用社会压力小鼠模型来证明，在雄性之间的攻击性相互作用后，血浆和下丘脑中的 NGF 水平都会增加。这项研究已扩展到包括人类在内的其他物种，结果表明，分娩、哺乳和第一次跳伞的预期也会导致 NGF 血浆水平增加以及淋巴细胞上 NGF 受体分布的变化。 BDNF 激活是由身体和社会压力事件引起的。本综述的目的是（1）概述目前对 NGF 和 BDNF 在脊椎动物应激相关生理变化中的作用的理解，特别是对于身体和心理应激源，它们可能激活相似和不同的神经生物学途径，以及（2）总结最近从不断增加的 BDNF 和 NGF 神经行为数据中得出药理学策略的努力。 (C) 2001 Elsevier Science Inc. 保留所有权利。
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are well-studied polypeptide growth factors involved in the development and maintenance of specific peripheral and central populations of neuronal cells. In addition to its role as a neurotrophic agent, NGF controls very complex functions in vertebrate physiology. A variety of cells outside the nervous system are in fact able to synthesize NGF including epithelial cells, fibroblasts, lymphocytes, and macrophages. NGF target cells have been identified in the nervous, immune. and endocrine systems, suggesting that NGF ma?; operate through multiple paths to ultimately regulate physiological homeostasis and behavioral coping. We used a mouse model of social stress to demonstrate that NGF levels increase both in plasma and in the hypothalamus following intermale aggressive interactions. The investigation has been extended to other species, including humans, to show that labour, lactation, and the anticipation of the first jump with a parachute also result in increased NGF plasma levels and in changes in the distribution of NGF receptors on lymphocytes. BDNF activation is caused by both physical and social stress events. The aim of this review is to (1) outline the current understanding of the roles of NGF and BDNF in stress-related physiological changes in vertebrates, in particular for physical vs, psychological stressors, which may activate both similar and different neurobiological pathways, and (2) summarize recent efforts to derive pharmacological strategies from the increasing body of BDNF and NGF neurobehavioral data. (C) 2001 Elsevier Science Inc. All rights reserved.