Functional Mapping of Face-Selective Regions in the Extrastriate Visual Cortex of the Marmoset
Functional Mapping of Face-Selective Regions in the Extrastriate Visual Cortex of the Marmoset
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DOI：
10.1523/jneurosci.2659-14.2015
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发表时间：
2015-01-21
影响因子：
5.3
通讯作者：
Silva, Afonso C.
中科院分区：
文献类型：
--
作者：
Hung, Chia-Chun;Yen, Cecil C.;Silva, Afonso C.
人类和猕猴的大脑皮层有专门的区域来处理面部和其他视觉刺激类别。目前还不清楚新大陆的猴子是否存在类似的功能组织，例如普通的绒猴（Callithrix jacchus），这是一种越来越受关注的神经科学灵长类模型。为了解决这个问题，我们测量了四只清醒的绒猴大脑中的选择性神经反应，这些绒猴被训练将目光固定在面部、身体、物体和控制模式的图像上。在两名受试者中，我们测量了高伽马范围的场电位从植入在枕叶和颞下皮层的大部分的皮层电图阵列。在另外两名受试者中，我们测量了整个大脑的BOLD fMRI反应。这两种技术都揭示了强大的，区域特定的模式的类别选择性神经反应。我们报告说，至少有六个面孔选择性补丁标记的绒猴枕颞通路，最前面的补丁显示出最强的偏好，面对其他刺激。这些斑块的外观与之前在猕猴和人类中的发现相似，包括它们在两个平行通路中的明显排列，表明面部处理网络的核心元素存在于生活在3500万年前的共同灵长类祖先中。研究结果还确定了绒猴作为一个可行的动物模型系统，用于研究与人类高级社会视觉感知相关的专门神经机制。
The cerebral cortex of humans and macaques has specialized regions for processing faces and other visual stimulus categories. It is unknown whether a similar functional organization exists in New World monkeys, such as the common marmoset (Callithrix jacchus), a species of growing interest as a primate model in neuroscience. To address this question, we measured selective neural responses in the brain of four awake marmosets trained to fix their gaze upon images of faces, bodies, objects, and control patterns. In two of the subjects, we measured high gamma-range field potentials from electrocorticography arrays implanted over a large portion of the occipital and inferotemporal cortex. In the other two subjects, we measured BOLD fMRI responses across the entire brain. Both techniques revealed robust, regionally specific patterns of category-selective neural responses. We report that at least six face-selective patches mark the occipitotemporal pathway of the marmoset, with the most anterior patches showing the strongest preference for faces over other stimuli. The similar appearance of these patches to previous findings in macaques and humans, including their apparent arrangement in two parallel pathways, suggests that core elements of the face processing network were present in the common anthropoid primate ancestor living similar to 35 million years ago. The findings also identify the marmoset as a viable animal model system for studying specialized neural mechanisms related to high-level social visual perception in humans.