Subthalamic nucleus stimulation modulates thalamic neuronal activity.
Subthalamic nucleus stimulation modulates thalamic neuronal activity.
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DOI：
10.1523/jneurosci.2027-08.2008
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发表时间：
2008-11-12
影响因子：
5.3
通讯作者：
Vitek, Jerrold L.
中科院分区：
文献类型：
--
作者：
Xu, Weidong;Russo, Gary S.;Hashimoto, Takao;Zhang, Jianyu;Vitek, Jerrold L.
丘脑底核（STN）脑深部刺激（DBS）是治疗晚期帕金森病的有效工具。然而，DBS发挥其有益作用的机制仍不清楚。我们以前报道过，在苍白球（GPi）的内部段的神经元活动的频率增加，并产生更有规律和周期性的模式。在这里，我们扩展我们的观察苍白球（腹侧部的口部（VLo）和腹前（VA））和小脑（腹侧部的口部后（VPLo））的运动丘脑接收区的神经元在DBS。刺激参数，产生改善刚度和运动迟缓导致的变化，在运动丘脑的两个区域相似的神经元活动的振荡活动的模式和功率。神经元在VA/VLo和VPLo往往变得更加周期性和规则的振荡活动从低到高频率的转变。在VA/VLo中爆发活动减少，但在VPLo中没有显著变化。VA/VLo神经元的群体也有显着的变化，在DBS过程中被抑制，而VPLo神经元往往被激活。这些数据与以下假设一致：DBS增加了核输出，并在基底神经节丘脑网络中产生了神经元活动模式和周期性的变化，并且这些变化包括可能通过激活相邻小脑-丘脑纤维束的小脑通路。
Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is an effective tool for the treatment of advanced Parkinson’s disease. The mechanism by which STN DBS elicits its beneficial effect, however, remains unclear. We previously reported STN stimulation increased the rate and produced a more regular and periodic pattern of neuronal activity in the internal segment of the globus pallidus (GPi). Here we extend our observations to neurons in the pallidal (ventralis lateralis pars oralis (VLo) and ventralis anterior (VA)) and cerebellar (ventralis lateralis posterior pars oralis (VPLo)) receiving areas of the motor thalamus during STN DBS. Stimulation parameters that produced improvement in rigidity and bradykinesia resulted in changes in the pattern and power of oscillatory activity of neuronal activity that were similar in both regions of the motor thalamus. Neurons in both VA/VLo and VPLo tended to become more periodic and regular with a shift in oscillatory activity from low to high frequencies. Burst activity was reduced in VA/VLo, but was not significantly changed in VPLo. There was also a significant shift in the population of VA/VLo neurons that were inhibited during STN DBS, while VPLo neurons tended to be activated. These data are consistent with the hypothesis that STN DBS increases output from the nucleus and produces a change in the pattern and periodicity of neuronal activity in the basal ganglia thalamic network, and that these changes include cerebellar pathways likely via activation of adjacent cerebello-thalamic fiber bundles.