Essential roles for the Abl and Arg tyrosine kinases in neurulation
Essential roles for the Abl and Arg tyrosine kinases in neurulation
复制标题
DOI：
10.1016/s0896-6273(00)80646-7
复制
发表时间：
1998-12-01
期刊：
影响因子：
16.2
通讯作者：
Baltimore, D
中科院分区：
文献类型：
--
作者：
Koleske, AJ;Gifford, AM;Baltimore, D
Abl和Arg酪氨酸激酶在中枢神经系统的发育和功能中起重要作用。精氨酸在成年小鼠脑中含量最丰富，尤其是在突触丰富的区域。Arg（-/-）小鼠发育正常，但表现出多种行为异常，这表明Arg（-/-）脑患有神经元功能缺陷。缺乏Abl和Arg的胚胎在神经胚形成中存在缺陷，并在胚胎发育后11天（dpc）前死亡。虽然它们正常分裂，但abl（-/-）arg（-/-）神经上皮细胞的肌动蛋白细胞骨架显示出明显的改变。我们发现，Abl和精氨酸colocalize彼此和肌动蛋白微丝在顶端表面的发展中的神经上皮。因此，Abl和Arg在神经形成中发挥重要作用，并可以调节肌动蛋白细胞骨架的结构。
The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions. arg(-/-) mice develop normally but exhibit multiple behavioral abnormalities, suggesting that arg(-/-) brains suffer from defects in neuronal function. Embryos deficient in both Abl and Arg suffer from defects in neurulation and die before 11 days postcoitum (dpc). Although they divide normally, abl(-/-)arg(-/-) neuroepithelial cells display gross alterations in their actin cytoskeleton. We find that Abl and Arg colocalize with each other and with actin microfilaments at the apical surface of the developing neuroepithelium. Thus, Abl and Arg play essential roles in neurulation and can regulate the structure of the actin cytoskeleton.