Design of long-term HIV dynamic studies using semiparametric mixed-effects models.
Design of long-term HIV dynamic studies using semiparametric mixed-effects models.
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使用半参数混合效应模型设计长期艾滋病毒动态研究。
DOI：
10.1002/bimj.200710440
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Zhu,Yiliang
中科院分区：
文献类型：
--
作者：
Huang,Yangxin;Park,Jeong-Gun;Zhu,Yiliang
Studies of HIV dynamics in AIDS research are very important in understanding the pathogenesis of HIV‐1 infection and also in assessing the effectiveness of antiviral therapies. There are many AIDS clinical trials on HIV dynamics currently in development worldwide, giving rise to many design issues yet to be addressed. For example, most studies are focused on short‐term viral dynamics and the existing models may not be applicable to describe long‐term virologic response. In this paper, we use a simulation‐based approach to study the designs of long‐term viral dynamics under semiparametric nonlinear mixed‐effects models. These models not only can preserve the meaningful interpretation of the short‐term HIV dynamics, but also characterize the long‐term virologic responses to antiretroviral (ARV) treatment. We investigate a number of feasible clinical protocol designs similar to those currently used in AIDS clinical trials. In particular, we evaluate whether earlier samplings can result in more useful information about the viral response trajectory; we also evaluate the effectiveness of two strategies: more frequent samplings per subject with fewer subjects versus fewer samplings per subject with more subjects while keeping the total number of samplings constant. The results of our investigation provide quantitative guidance for designing and selecting ARV therapy. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
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影响因子：
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作者：
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DOI：
10.1073/pnas.82.4.1074
发表时间：
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影响因子：
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