The effect of corticosteroids on human epidermal mitotic activity.
The effect of corticosteroids on human epidermal mitotic activity.
复制标题
皮质类固醇对人表皮有丝分裂活性的影响。
DOI：
10.1001/archderm.1971.04000130041005
复制
发表时间：
1971
影响因子：
--
通讯作者：
H. Maibach
中科院分区：
文献类型：
--
作者：
L. Fisher;H. Maibach
皮质激素类药物的作用已在其对人体皮肤的抗有丝分裂活性方面进行了研究。对于局部研究，从每名志愿者的前臂采集两个4 mm活检组织，以允许使用配对比较方法;单独的对照组用于口腔研究。结果表明，口服给药的曲安奈德和局部给药的曲安奈德抑制有丝分裂活动的表皮。局部给予0.2%醋酸氟轻松证明同样有效，虽然没有效果时，使用0.025%。醋酸氢化可的松局部给药后未观察到有丝分裂抑制。然而，反复注射促肾上腺皮质激素导致有丝分裂活性显著下降。皮质类固醇的抗有丝分裂活性似乎与其疗效有关。这可以补充血管收缩剂测定，用于针对具有增加的细胞更新的那些疾病。
The action of the corticoid drugs has been investigated in regard to their antimitotic activity on human skin. For topical studies two 4-mm biopsies were taken from the forearms of each volunteer to allow use of the paired comparison method; a separate control group was used for oral studies. The results indicated that orally administered triamcinolone and topically administered triamcinolone acetonide inhibited mitotic activity of the epidermis. Topically administered 0.2% fluocinolone acetonide proved equally potent, although no effect was seen when 0.025% was used. No mitotic inhibition was observed after topical administration of hydrocortisone acetate. Repeated injections of corticotropin, however, resulted in a significant fall in mitotic activity. The antimitotic activity of the corticosteroids seems to be related to their therapeutic efficacy. This may supplement the vasoconstrictor assay for pertinence to those diseases with increased cell turnover.