Predicting clinical progression or death in subjects with early-stage human immunodeficiency virus (HIV) infection: a comparative analysis of quantification of HIV RNA, soluble tumor necrosis factor type II receptors, neopterin, and beta2-microglobulin. M
Predicting clinical progression or death in subjects with early-stage human immunodeficiency virus (HIV) infection: a comparative analysis of quantification of HIV RNA, soluble tumor necrosis factor type II receptors, neopterin, and beta2-microglobulin. M
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预测早期人类免疫缺陷病毒 (HIV) 感染受试者的临床进展或死亡：HIV RNA、可溶性肿瘤坏死因子 II 型受体、新蝶呤和 β2 微球蛋白定量的比较分析。
DOI：
10.1086/514108
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Bilello,J
中科院分区：
文献类型：
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作者：
Stein,DS;Lyles,RH;Graham,NM;Tassoni,CJ;Margolick,JB;Phair,JP;Rinaldo,C;Detels,R;Saah,A;Bilello,J
通过支链DNA信号扩增定量人类免疫缺陷病毒（HIV）RNA，测量可溶性肿瘤坏死因子II型受体（sTNFR-II）、新蝶呤、b2-微球蛋白或CD 4细胞计数可用于预测HIV感染的临床进展或死亡风险，但未在同一研究中进行比较。90例受试者根据其CD 4细胞下降率分为进展组，并根据初始CD 4细胞计数、年龄、人种和日历时间匹配为三胞胎。通过匹配的逻辑回归，只有sTNFR-II和HIV RNA值可以预测进展组的结局。基线HIV RNA和sTNFR-II的分类导致进展至几种临床结局的差异。sTNFR-II浓度是唯一的免疫标记物，增加了HIV RNA测定在早期受试者中的预后效用。需要在疾病后期或治疗后进行进一步研究。
Quantification of human immunodeficiency virus (HIV) RNA by branched-chain DNA signal amplification, measurement of soluble tumor necrosis factor type II receptors (sTNFR-II), neopterin, b2-microglobulin, or CD4 cell counts can be used to predict the risk of clinical progression or death in HIV infection but have not been compared in the same study. Ninety subjects were categorized into progression groups by their rate of CD4 cell decline and matched into triplets by initial CD4 cell count, age, race, and calendar time. By matched logistic regression, only the sTNFR-II and HIV RNA values were predictive of outcome across the progression groups. Categorization of baseline HIV RNA and sTNFR-II resulted in differences in progression to several clinical outcomes. sTNFR-II concentrations were the only immune marker examined that increased the prognostic utility of HIV RNA determination in early-stage subjects. Further studies in later stages of disease or after therapy are indicated.