I forgot when I lost my grip-strong associations between cognition and grip strength in level of performance and change across time in relation to impending death
I forgot when I lost my grip-strong associations between cognition and grip strength in level of performance and change across time in relation to impending death
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DOI：
10.1016/j.neurobiolaging.2015.11.010
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发表时间：
2016-02-01
影响因子：
4.2
通讯作者：
Hassing, Linda B.
中科院分区：
文献类型：
--
作者：
Bjork, Marcus Praetorius;Johansson, Boo;Hassing, Linda B.
认知功能水平和握力之间的关联已经得到了很好的建立，而这两种功能变化的纵向关联的证据仍然不清楚。我们在一个基于人群的样本中研究了认知和握力在表现水平和晚年纵向变化方面的相关性，基线时年龄≥ 80岁，随访至死亡。样本由449名非痴呆个体组成，来自OCTO双胞胎研究。评估6个认知领域和握力的测试组合在5个场合进行，测量间隔为2年。我们拟合了死亡时间双变量增长曲线模型，调整了年龄，教育和性别，导致握力和认知在两个水平的性能（在所有认知领域）和变化率（在6个领域中的4个）之间的关联。这些结果表明，认知和握力在晚年共同变化，并且认知和握力之间的关联在死亡前比生命早期更强。(C)2016作者爱思唯尔公司出版这是CC BY-NC-ND许可下的开放获取文章。
An association between level of cognitive function and grip strength is well established, whereas evidence for longitudinal associations of change in the 2 functions is still unclear. We examined associations between cognition and grip strength in levels of performance and in longitudinal change in late life in a population-based sample, aged >= 80 years at baseline, followed until death. The sample consisted of 449 nondemented individuals drawn from the OCTO-Twin Study. A test battery assessing 6 cognitive domains and grip strength was administered at 5 occasions with measurements intervals of 2 years. We fitted time to death bivariate growth curve models, adjusted for age, education, and sex which resulted in associations between grip strength and cognition in both levels of performance (across all cognitive domains) and rates of change (in 4 of 6 domains). These results show that cognition and grip strength change conjointly in later life and that the association between cognition and grip strength is stronger before death than earlier in life. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.