Expression of the liver X receptor α and β in embryonic and adult mice
Expression of the liver X receptor α and β in embryonic and adult mice
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DOI：
10.1002/ar.a.20015
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发表时间：
2004-04-01
期刊：
影响因子：
--
通讯作者：
Auwerx, J
中科院分区：
文献类型：
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作者：
Annicotte, JS;Schoonjans, K;Auwerx, J
我们的特点是表达模式的核受体肝X受体（LXR）α和β在小鼠胚胎发育和成年期的原位杂交实验。LXR α和LXR β在肝移植后11.5天开始检测。后来，LXR α表达在参与脂质稳态的器官中保持高水平，如肝脏、肠和棕色脂肪组织，而LXR β在神经元和内分泌来源的组织中更普遍表达和富集。(C)2004 Wiley-Liss，Inc.
We characterized the expression pattern of the nuclear receptors liver X receptor (LXR) alpha and beta during mouse embryonic development and in adulthood by in situ hybridization experiments. LXRalpha and LXRbeta are detected in the liver starting at 11.5 days postcoitum. Later, LXRalpha expression remains high in organs involved in lipid homeostasis, such as liver, intestine, and brown adipose tissue, whereas LXRbeta is more ubiquitously expressed and enriched in tissues of neuronal and endocrine origin. (C) 2004 Wiley-Liss, Inc.