Clinical Features of Congenital and Developmental Cataract in East China: A Five-year Retrospective Review.
Clinical Features of Congenital and Developmental Cataract in East China: A Five-year Retrospective Review.
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华东地区先天性和发育性白内障的临床特征：五年回顾性研究
DOI：
10.1038/s41598-017-04332-1
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发表时间：
2017-06-26
影响因子：
4.6
通讯作者：
Lu Y
中科院分区：
文献类型：
--
作者：
Zhu X;Du Y;He W;Sun T;Zhang Y;Chang R;Zhang K;Lu Y
先天性/发育性白内障是全世界儿童失明的一个重要原因。充分了解临床特征对于早期诊断和适当治疗以预防不可逆性视力损害至关重要。本文对上海复旦大学中国眼科医院5年来收治的520例先天性/发育性白内障的临床资料进行了回顾性分析。总结其临床特点，包括手术年龄、主诉、首次发现白内障相关症状与手术的间隔时间等。56.3%的儿童为双侧。手术时年龄从0.25岁到17.4岁，只有9.2%的人接受了1年以下的手术。从最初的表现到手术的间隔时间从2天到17年不等。67例患者伴有先天性异常，其中持续性玻璃体增生性疾病和先天性心脏病是最常见的眼部和全身疾病。斜视和眼球震颤分别占20.6%和11.9%。在伴有斜视的双眼白内障患者中，内斜视患眼的眼轴长度在统计学上短于外斜视患眼。这些发现为了解中国先天性/发育性白内障的特点提供了信息，并可能有助于实现对这些病例的综合治疗策略。
Congenital/developmental cataract is a significant cause of blindness in children worldwide. Full knowledge of clinical features is essential for early diagnosis and proper treatment to prevent irreversible visual impairment. We conducted a retrospective chart review on 520 congenital/developmental cataract cases based on a five-year clinical data from Eye and ENT Hospital of Fudan University, Shanghai, China. Clinical features including age at the surgery, chief complaints, interval between initial identification of cataract-related manifestations and surgery, etc. were summarized. 56.3% of children were bilateral. The age at surgery ranged from 0.25 to 17.4 years, only 9.2% receiving surgery below 1 year. Interval between initial identification of manifestations and surgery ranged from 2 days to 17 years. Concomitant congenital abnormalities were present in 67 patients, with persistent hyperplastic primary vitreous and congenital heart disease as the most frequent ocular and systemic disorders. Strabismus and nystagmus were seen in 20.6% and 11.9% of patients. In bilateral cataract patients with strabismus, axial lengths of esotropia-affected eyes were statistically shorter than exotropia-affected eyes. These findings provide information on characteristics of congenital/developmental cataract in China and may assist in achievement of comprehensive treating strategies in these cases.