Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection
Tracking Salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection
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DOI：
10.1016/s1074-7613(02)00289-3
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发表时间：
2002-03-01
期刊：
影响因子：
32.4
通讯作者：
Jenkins, MK
中科院分区：
文献类型：
--
作者：
McSorley, SJ;Asch, S;Jenkins, MK
一种新的过继转移系统被用来跟踪幼稚的沙门氏菌特异性CD4T细胞在体内的命运。这些细胞早在口腔感染后3小时就在Peyer‘s斑块显示出激活的迹象。然后，激活的CD4T细胞产生IL-2，并在这些组织的T细胞区增殖，然后迁移到富含B细胞的滤泡中。相比之下，沙门氏菌特异性的CD4T细胞在脾中没有被激活，尽管这两个器官中都存在细菌，但这些细胞中很少有迁移到肝脏的。这些结果表明，T细胞对致病性沙门氏菌感染的反应局限于肠道相关淋巴组织，而不能有效地延伸到晚期感染的主要部位。
A novel adoptive transfer system was used to track the fate of naive Salmonella-specific CD4 T cells in vivo. These cells showed signs of activation in the Peyer's patches as early as 3 hr after oral infection. The activated CD4 T cells then produced IL-2 and proliferated in the T cell areas of these tissues before migrating into the B cell-rich follicles. In contrast, Salmonella-specific CD4 T cells were not activated in the spleen and very few of these cells migrated to the liver, despite the presence of bacteria in both organs. These results show that the T cell response to pathogenic Salmonella infection is localized to the gut-associated lymphoid tissue and does not extend efficiently to the major sites of late infection.