Serum enterolactone levels and the risk of breast cancer in women with palpable cysts
Serum enterolactone levels and the risk of breast cancer in women with palpable cysts
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DOI：
10.1016/s0959-8049(03)00576-8
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发表时间：
2004-01-01
影响因子：
8.4
通讯作者：
Rubagotti, A
中科院分区：
文献类型：
--
作者：
Boccardo, F;Lunardi, G;Rubagotti, A
据报道，低水平的木脂素，即肠内酯，与一般女性人群中乳腺癌风险增加有关。我们回顾性评估了血清肠内酯浓度与可触及囊肿的女性乳腺癌发生率之间的关系。采用时间分辨荧光免疫分析法（TR-FIA）测定了383例首次囊肿抽吸时可触及囊肿的女性冷冻保存血清中肠内酯的水平。在中位随访时间为6.5年（范围为0.5-12.75年）后，发现18名妇女患上了浸润性乳腺癌。随后发生乳腺癌的女性血清肠内酯的中位值显著较低：8.5 nM/l vs 16.0 nM/l：P= 0.04。乳腺癌的比值比（OR）分别为：0.36（P = 0.03）、0.57（P = 0.3）和0.38（P=0.25），第25（8 nM/l）、50（16 nM/l）和75（24 nM/l）百分位数。受试者工作特征（ROC）分析显示肠内酯作为乳腺癌风险指标的准确性令人满意（曲线下面积（AUC）=0.64：P=0.04）。Logistic回归分析证实，肠内酯浓度对乳腺癌的风险有很强的保护作用。这些研究结果可能具有重要的临床意义方面的干预饮食为重点的化学预防试验。(C)2003 Elsevier Ltd.保留所有权利。
Low levels of lignans, namely enterolactone, have been reported to be associated with an increased risk of breast cancer in the general female population. We assessed, retrospectively, the relationship between serum enterolactone concentrations and the occurrence of breast cancer in women with palpable cysts. The levels of enterolactone in cryopreserved serum aliquots, obtained from 383 women with palpable cysts at the time of their first cyst aspiration, were measured using a time-resolved fluoro-immunoassay (TR-FIA). After a median follow-up time of 6.5 years (range 0.5-12.75 years), 18 women were found to have developed an invasive breast cancer. Median values of serum enterolactone were significantly lower in women who subsequently developed breast cancer: 8.5 nM/l versus 16.0 nM/l: P= 0.04. Odd Ratios (OR) for breast cancer were: 0.36 (P = 0.03), 0.57 (P = 0.3) and 0.38 (P=0.25) for 25th (8 nM/l), 50th (16 nM/l) and 75th (24 nM/l) percentile values, respectively. The receiver operating characteristic (ROC) analysis showed a satisfactory accuracy for enterolactone as a breast cancer risk indicator (area under the curve (AUC)=0.64: P=0.04). Logistic regression analysis confirmed that the enterolactone concentration had a strong protective effect on the breast cancer risk. These findings may have important clinical implications with regard to interventional diet-focused chemo-preventive trials. (C) 2003 Elsevier Ltd. All rights reserved.