Arabidopsis SMALL ORGAN 4, a homolog of yeast NOP53, regulates cell proliferation rate during organ growth.
Arabidopsis SMALL ORGAN 4, a homolog of yeast NOP53, regulates cell proliferation rate during organ growth.
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DOI：
10.1111/jipb.12424
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发表时间：
2015-10
影响因子：
11.4
通讯作者：
Xiao-Ran Zhang;Zhixiang Qin;Xiao Zhang;Yuxin Hu
中科院分区：
文献类型：
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作者：
Xiao-Ran Zhang;Zhixiang Qin;Xiao Zhang;Yuxin Hu
细胞增殖是植物器官发生所必需的基本事件，并且对最终器官的大小有很大影响。尽管植物细胞增殖的控制已被广泛研究，但植物如何设定单个器官所需的细胞数量在很大程度上是难以捉摸的。在这里，我们描述了拟南芥小器官 4 (SMO4)，其在调节细胞增殖速率以及最终器官大小方面发挥作用。 smo4突变体由于细胞数量减少而表现出器官尺寸减小，进一步分析表明这种表型是器官发育过程中细胞周期进程延迟的结果。 SMO4 编码酿酒酵母中核仁蛋白 53 (NOP53) 的同源物，主要在细胞增殖的组织中表达。然而，进一步的互补测试表明SMO4不能挽救酿酒酵母NOP53突变体的致命缺陷。这些结果将 SMO4 定义为器官生长过程中细胞增殖的重要调节因子，并表明 SMO4 可能在进化上与 NOP53 不同。
Cell proliferation is a fundamental event essential for plant organogenesis and contributes greatly to the final organ size. Although the control of cell proliferation in plants has been extensively studied, how the plant sets the cell number required for a single organ is largely elusive. Here, we describe the Arabidopsis SMALL ORGAN 4 (SMO4) that functions in the regulation of cell proliferation rate and thus final organ size. The smo4 mutant exhibits a reduced size of organs due to the decreased cell number, and further analysis reveals that such phenotype results from a retardation of the cell cycle progression during organ development. SMO4 encodes a homolog of NUCLEOLAR PROTEIN 53 (NOP53) in Saccharomyces cerevisiae and is expressed primarily in tissues undergoing cell proliferation. Nevertheless, further complementation tests show that SMO4 could not rescue the lethal defect of NOP53 mutant of S. cerevisiae. These results define SMO4 as an important regulator of cell proliferation during organ growth and suggest that SMO4 might have been evolutionarily divergent from NOP53.