Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure
Programming effects in sheep of prenatal growth restriction and glucocorticoid exposure
复制标题
DOI：
10.1152/ajpregu.2001.281.3.r960
复制
发表时间：
2001-09-01
影响因子：
2.8
通讯作者：
Newnham, JP
中科院分区：
文献类型：
--
作者：
Moss, TJM;Sloboda, DM;Newnham, JP
我们的目的是确定在妊娠晚期单次和重复注射糖皮质激素的产后影响。重复（104、111、118、125天）或单次（104天）注射倍他米松或生理盐水给母羊或通过超声引导注射给胎儿（足月150天）。羔羊自发出生，并在3个月和6个月和1岁的年龄进行了研究。在每个年龄段测量动脉压，并在6个月和1岁时进行静脉葡萄糖耐量试验。重复母体注射倍他米松，但不是单一母体或胎儿，延长妊娠，降低出生时和3个月的体重，并与低动脉压在3个月，但不是在6个月和1年。无论注射次数或途径如何，所有倍他赛治疗组的葡萄糖代谢均发生改变。我们的数据表明，糖皮质激素诱导的胎儿生长受限与出生后动脉压的短暂降低有关，但糖皮质激素暴露与或不与生长受限改变葡萄糖代谢。
Our aim was to determine the postnatal effects of single and repeated glucocorticoid injections during late gestation. Repeated (104, , 111, 118, 125 days) or single (104 days) injections of betamethasone or saline were given to the ewe or by ultrasound guided injection to the fetus (term 150 days). Lambs were born spontaneously and studied at 3 and 6 mo and 1 yr of age. Arterial pressure was measured at each age, and we performed intravenous glucose tolerance tests at 6 mo and 1 yr. Repeated maternal, but not single maternal or fetal, betamethasone injections prolonged gestation, reduced weight at birth and 3 mo, and was associated with low arterial pressure at 3 mo but not at 6 mo and 1 yr. Glucose metabolism was altered in all betamethasone treatment groups, regardless of the number or route of injections. Our data demonstrate that glucocorticoid-induced fetal growth restriction is associated with a transient reduction in postnatal arterial pressure, but glucocorticoid exposure with or without growth restriction alters glucose metabolism.