Diabetes Mellitus and Risk of Colorectal Cancer Mortality in Japan: the Japan Collaborative Cohort Study.
Diabetes Mellitus and Risk of Colorectal Cancer Mortality in Japan: the Japan Collaborative Cohort Study.
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DOI：
10.22034/apjcp.2016.17.10.4681
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发表时间：
2016-10-01
期刊：
影响因子：
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通讯作者：
Tamakoshi A
中科院分区：
文献类型：
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作者：
Tan C;Mori M;Adachi Y;Wakai K;Suzuki S;Suzuki K;Hashimoto Sh;Watanabe Y;Tamakoshi A
我们的目的是估计糖尿病（DM）是否可能与日本结直肠癌（CRC）死亡风险增加有关。日本协同队列（JACC）研究是一项全国性的前瞻性研究，于1988年启动，涉及110585名受试者（年龄范围：40 - 79岁；46395名男性和64190名女性）。我们目前的分析人群包括96,081人（40,510名男性和55,571名女性），他们提供了糖尿病病史的详细信息。问卷还包括年龄、性别、体重、身高、结直肠癌家族史、吸烟、饮酒和运动习惯以及教育程度。采用Cox比例风险回归估计风险比（HR）。采用SPSS 21软件对所有数据进行分析。在患有糖尿病的参与者中，我们随访了71,174人年和640人。CRC造成的死亡得到确认；在非糖尿病参与者中，在1,499,324人年期间确定了785例结直肠癌死亡。在调整了年龄、性别、体重指数（BMI）、结直肠癌家族史、吸烟习惯、饮酒习惯、体育活动（运动和步行）和教育等多因素混杂因素后，DM与结直肠癌死亡风险增加相关（HR 1.4, 95%可信区间[CI] 1.0-2.0）。女性糖尿病患者，而男性糖尿病患者，CRC死亡率增加（HR 1.7, 95% CI 1.0-3.0）。男性和女性糖尿病患者的结直肠癌死亡风险显著增加，但在日本男性糖尿病患者中未见显著增加。
Our aim was to estimate whether diabetes mellitus (DM) may be associated with an increased risk of colorectal cancer (CRC) mortality in Japan. The Japan Collaborative Cohort (JACC) Study is a nationwide prospective study, initiated in 1988, which involves 110,585 subjects (age range: from 40 to 79 years; 46,395 males and 64,190 females). Our present analysis population comprised 96,081 (40,510 men and 55,571 women) who provided details on DM history. The questionnaire also included age, sex, weight, height, family history of CRC, smoking, drinking and exercise habits, and education. Cox proportional-hazard regression was used to estimate the hazard ratio (HR). We used SPSS 21 software to analyze all data. Among the participants with DM, we followed up for 71,174 person-years and 640. deaths from CRC were confirmed; and, among the non-diabetic participants, 785 CRC deaths were identified during 1,499,324 person-years. After adjusting for multivariate confounding factors, such as age, sex, body mass index (BMI), family history of colorectal cancer, smoking habit, drinking habit, physical activity (sports and walking) and education, DM was associated with an increased risk of CRC death (HR 1.4, 95% confidence interval [CI] 1.0-2.0). Diabetic women, but not diabetic men, experienced increased mortality from CRC (HR 1.7, 95% CI 1.0-3.0). The risk of CRC mortality is significantly increased in both sexes and women with diabetes, but no significant increase was seen for diabetic men among Japanese.