Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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胃癌腹膜转移的基因调控和靶向治疗：双能CT和PET/CT的影像学发现
DOI：
10.3791/56526
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发表时间：
2018-01-01
影响因子：
1.2
通讯作者：
Zhang, Huan
中科院分区：
文献类型：
--
作者：
Shi, Bowen;Lin, Huimin;Zhang, Huan
胃癌仍然是全球第四大癌症发病率，5年生存率仅为20%-30%。腹膜转移是不可切除胃癌最常见的转移类型，是预后的决定性因素。预防和控制腹膜转移的发生对延长胃癌患者的生存期具有重要意义。一种无创、高效的影像学技术将有助于我们识别腹膜转移瘤的侵袭和转移过程，并监测肿瘤结节对治疗的反应。这将使我们能够准确地描述胃癌的发展过程和分子机制。我们最近描述了使用双能CT（DECT）和正电子发射断层扫描/计算机断层扫描（PET/CT）平台检测和监测裸鼠模型中的胃肿瘤转移的实验。我们已经证明，每周连续监测DECT和PET/CT可以识别腹膜转移的动态变化。sFRP1过表达的胃癌小鼠模型放射学表现阳性，FDG摄取增高，增强程度增加，TGF-β 1抑制剂靶向治疗后结节SUVmax（standardized uptake value）有明显改变趋势。在这篇文章中，我们描述了详细的非侵入性成像程序进行更复杂的研究胃癌腹膜转移的动物模型，并提供了代表性的成像结果。非侵入性成像技术的使用将使我们能够更好地了解肿瘤发生的机制，监测肿瘤生长，并评估胃癌治疗干预措施的效果。
Gastric cancer remains fourth in cancer incidence worldwide with a five-year survival of only 20%-30%. Peritoneal metastasis is the most frequent type of metastasis that accompanies unresectable gastric cancer and is a definitive determinant of prognosis. Preventing and controlling the development of peritoneal metastasis could play a role in helping to prolong the survival of gastric cancer patients. A non-invasive and efficient imaging technique will help us to identify the invasion and metastasis process of peritoneal metastasis and to monitor the changes in tumor nodules in response to treatments. This will enable us to obtain an accurate description of the development process and molecular mechanisms of gastric cancer. We have recently described experiment using dual energy CT (DECT) and positron emission tomography/computed tomography (PET/CT) platforms for the detection and monitoring of gastric tumor metastasis in nude mice models. We have shown that weekly continuous monitoring with DECT and PET/CT can identify dynamic changes in peritoneal metastasis. The sFRP1-overexpression in gastric cancer mice models showed positive radiological performance, a higher FDG uptake and increasing enhancement, and the SUVmax (standardized uptake value) of nodules demonstrated an obvious alteration trend in response to targeted therapy of TGF-beta 1 inhibitor. In this article, we described the detailed non-invasive imaging procedures to conduct more complex research on gastric cancer peritoneal metastasis using animal models and provided representative imaging results. The use of non-invasive imaging techniques should enable us to better understand the mechanisms of tumorigenesis, monitor tumor growth, and evaluate the effect of therapeutic interventions for gastric cancer.