COMPARATIVE VIRULENCE OF SOME ENGLISH STRAINS OF HAEMOPHILUS-PLEUROPNEUMONIAE SEROTYPE-2 AND SEROTYPE-3 IN THE PIG
COMPARATIVE VIRULENCE OF SOME ENGLISH STRAINS OF HAEMOPHILUS-PLEUROPNEUMONIAE SEROTYPE-2 AND SEROTYPE-3 IN THE PIG
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DOI：
10.1016/s0034-5288(18)30684-2
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发表时间：
1987-03-01
影响因子：
2.4
通讯作者：
SMITH, IM
中科院分区：
文献类型：
--
作者：
BRANDRETH, SR;SMITH, IM
将107.5和108.1之间的四种英国和一种丹麦胸膜肺炎嗜血杆菌血清型2菌株和五种英国血清型3菌株的活生物体鼻内接种到常规猪组中。在两种血清型的英国分离株中，有强毒株和无毒株。包括丹麦株在内的四种血清型 2 菌株和两种血清型 3 菌株在各组中的五头猪中的至少三头中产生了不同程度的肺实变，伴有脓肿形成和胸膜炎。除一种情况外，所有肺部病变均分离出胸膜肺炎幽门螺杆菌，通常从扁桃体分离，但较少从呼吸道其他部位分离。感染血清型 3 的一只动物出现化脓性关节炎和腱鞘炎。除后一头猪外，除了发热反应外，没有检测到任何临床症状，这反映了各组胸部病变的普遍性。在三分之二出现病变的猪中，通过间接免疫荧光检测到体液抗体反应，但只有少数猪通过补体结合检测到体液抗体反应。
Between 107.5 and 108.1 viable organisms of four English and one Danish strain of Haemophilus pleuropneumoniae serotype 2 and five English strains of serotype 3 were inoculated intranasally into groups of conventional pigs. Among the English isolates of both serotypes there were virulent and non-virulent strains. Four of the serotype 2 strains, including the Danish strain, and two of the serotype 3 strains produced varying degrees of pulmonary consolidation with abscess formation and pleurisy in at least three of the five pigs in the individual groups. H. pleuropneumoniae was isolated from the pulmonary lesions in all save one instance, frequently from the tonsil but less frequently from other parts of the respiratory tract. Purulent arthritis and tenosynovitis developed in one animal infected with serotype 3. Apart from the latter pig no clinical signs of illness were detected except for febrile reactions which reflected the prevalence of the thoracic lesions in the various groups. A humoral antibody response was detected by indirect immunofluorescence in two-thirds of the pigs which developed lesions but in fewer by complement fixation.