Magnesium Status, Genetic Variants of Magnesium-Related Ion Channel Transient Receptor Potential Membrane Melastatin 6 (TRPM6) and the Risk of Gestational Diabetes Mellitus in Chinese Pregnant Women: A Nested Case-Control Study
Magnesium Status, Genetic Variants of Magnesium-Related Ion Channel Transient Receptor Potential Membrane Melastatin 6 (TRPM6) and the Risk of Gestational Diabetes Mellitus in Chinese Pregnant Women: A Nested Case-Control Study
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DOI：
10.1002/mnfr.202200835
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发表时间：
2023-09-27
影响因子：
5.2
通讯作者：
Yang，Xuefeng
中科院分区：
文献类型：
--
作者：
Huang，Shanshan;Ge，Yanyan;Yang，Xuefeng
ScopeMagnesium plays an important role in regulating glucose metabolism. The study attempts to explore association between magnesium status and single nucleotide polymorphisms (SNPs) of gene involved in magnesium absorption‐transient receptor potential membrane melastatin 6 (TRPM6) and gestational diabetes mellitus (GDM) riskMethods and resultsA nested case–control study including 170 GDM cases and matched 340 controls is conducted based on Tongji Birth Cohort. Dietary, serum, and urine magnesium are evaluated before the diagnosis of GDM. Compared to the lowest tertile, women in the highest tertile of serum magnesium are at a lower risk of GDM (adjusted odds ratio [aOR] 0.42, 95% confidence intervals [CI] 0.21–0.84). Serum magnesium is inversely associated with insulin and homeostatic model assessment of insulin resistance (β= −0.05,p= 0.002;β= −0.04,p= 0.001, respectively). The aOR for GDM in carriers of the CT or CC genotypes ofTRPM6rs2274924 compared with carriers of the TT genotype is 2.76 (95% CI 1.78–4.26). Dietary magnesium is positively associated with serum magnesium (β= 0.02,p= 0.004), but not with GDM risk.ConclusionSerum magnesium and theTRPM6rs2274924 polymorphism are associated with the risk of GDM.
