Effects of aerosolized rabies virus exposure on bats and mice
Effects of aerosolized rabies virus exposure on bats and mice
复制标题
DOI：
10.1086/512616
复制
发表时间：
2007-04-15
影响因子：
6.4
通讯作者：
Bowen, Richard A.
中科院分区：
文献类型：
--
作者：
Davis, April D.;Rudd, Robert J.;Bowen, Richard A.
在1956年至1977年期间，4例狂犬病毒感染病例归因于雾化狂犬病毒;然而，自20世纪60年代末以来，几乎没有做过任何工作来解决这个问题。采用现代化的雾化设备，结合血清学、细胞培养和分子技术，我们继续调查雾化狂犬病病毒作为一种潜在的传播途径。通过气溶胶将实验室小鼠和2种蝙蝠暴露于狂犬病病毒的3种变体。所有蝙蝠在暴露于雾化狂犬病病毒后存活下来，并产生狂犬病中和抗体。有几只老鼠因接触气溶胶而死于狂犬病。在对动物进行狂犬病病毒肌内攻击之前，对抗体应答进行6个月的跟踪。尽管存在中和抗体，但蝙蝠对挑战的保护很差。
Between 1956 and 1977, 4 human cases of rabies virus infection were attributed to aerosolized rabies virus; however, little work has been done to address this topic since the late 1960s. Employing modern nebulization equipment coupled with serologic, cell culture, and molecular technology, we have continued the investigation into aerosolized rabies virus as a potential route of transmission. Laboratory mice and 2 species of bats were exposed, through aerosol, to 3 variants of rabies virus. All bats survived exposure to aerosolized rabies virus and produced rabies neutralizing antibody. Several mice died of rabies as a result of aerosol exposure. Antibody response was followed for 6 months before animals were given an intramuscular challenge of rabies virus. Poor protection from challenge was afforded in bats, despite the presence of neutralizing antibodies.