Adipose-derived stem cell exosomes facilitate rotator cuff repair by mediating tendon-derived stem cells
Adipose-derived stem cell exosomes facilitate rotator cuff repair by mediating tendon-derived stem cells
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DOI：
10.2217/rme-2021-0004
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发表时间：
2021-04-16
影响因子：
2.7
通讯作者：
Yin, Feng
中科院分区：
文献类型：
--
作者：
Fu, Guojian;Lu, Liangyu;Yin, Feng
目的：评价脂肪源性干细胞外泌体（ADSC-exos）通过介导肌腱源性干细胞（tdsc）修复肩袖的潜在能力并探讨其机制。方法：首先，我们在体外研究ADSC-exos存在下tdsc的生长、存活和迁移。利用大鼠肩袖损伤模型分析ADSC-exos促进体内肩袖愈合的能力。结果：ADSC-exos水凝胶能明显促进成骨和成脂分化，增强RUNX2、Sox-9、TNMD、TNC和Scx的表达及关节部分力学性能。结论：ADSC-exos具有通过介导tdsc促进肩袖修复的潜力。
Aim: To evaluate the potential capability of adipose-derived stem cell exosomes (ADSC-exos) on rotator cuff repair by mediating the tendon-derived stem cells (TDSCs) and explored the mechanism. Methods: First, we investigated the growth, survival and migration of TDSCs in the presence of ADSC-exos in vitro. Using a rat rotator cuff injury model to analyze the ability of the ADSC-exos to promote rotator cuff healing in vivo. Results: The hydrogel with ADSC-exos significantly improved the osteogenic and adipogenesis differentiation and enhanced the expression of RUNX2, Sox-9, TNMD, TNC and Scx and the mechanical properties of the articular portion. Conclusion: The ADSC-exos have the potential to promote the rotator cuff repair by mediating the TDSCs.[GRAPHICS].