Management of CNS germinoma.
Management of CNS germinoma.
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DOI：
10.2217/cns.15.13
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Allen, Jeffrey C
中科院分区：
文献类型：
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作者：
Osorio, Diana S;Allen, Jeffrey C
以下是中枢神经系统生殖细胞瘤治疗的总体概述。在过去的 35 年里，中枢神经系统生殖细胞瘤已成为预后最好的儿科脑肿瘤之一，5 年总生存率超过 85%。这部分是由于生殖细胞瘤对化疗和放疗非常敏感。未来的一些主要挑战将是找到方法来最大限度地减少治疗的副作用，特别是在放射方面，并改善患有神经系统、神经认知和/或内分泌缺陷的患者的生活质量。
The following is a general overview of the management of CNS germinomas. Over the last 35 years, CNS germinomas have become one of the pediatric brain tumors with the best outcomes with a greater than 85% overall survival over 5 years. This is in part due to the fact that germinomas are very responsive to chemotherapy and radiation. Some of the major challenges going forward will be to find ways to minimize the adverse effects of our treatments particularly with regard to radiation and to improve the quality of life of patients who develop neurologic, neurocognitive and/or endocrine deficiencies.