miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1
miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1
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DOI：
10.3892/or.2015.4025
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发表时间：
2015-08-01
期刊：
影响因子：
4.2
通讯作者：
Zhang, Qingyuan
中科院分区：
文献类型：
--
作者：
Lu, Kangping;Wang, Jingxuan;Zhang, Qingyuan
微小RNA（miRNAs）在乳腺癌中经常异常表达，并被认为在其发生和发展中起作用。在本研究中，我们发现miR-24- 3 p在乳腺癌中的表达水平与癌旁正常组织中的水平相比上调。过表达miR-24- 3 p可促进MDA-MB-435和MDA-MB-468细胞增殖，抑制细胞凋亡。利用生物信息学方法进一步证实p27 Kip 1是miR-24- 3 p的直接靶点，其蛋白水平受miR-24- 3 p负调控。因此，本文报道的数据表明，miR-24- 3 p是乳腺癌中的重要调节因子，并暗示miR-24- 3 p/p27 Kip 1轴具有作为乳腺癌治疗靶点的潜力。
MicroRNAs (miRNAs) are often aberrantly expressed in breast cancer and are postulated to play a role in its initiation and progression. In the present study, we found that the expression level of miR-24-3p was upregulated in breast cancer in comparison with the level in adjacent normal tissues. Overexpression of miR-24-3p was able to promote cell proliferation and inhibit cell apoptosis in MDA-MB-435 and MDA-MB-468 cells. With the bioinformatic method, we further identified that p27Kip1 is a direct target of miR-24-3p, and its protein level was negatively regulated by miR-24-3p. Therefore, the data reported here demonstrate that miR-24-3p is an important regulator in breast cancer, and imply that the miR-24-3p/p27Kip1 axis has potential as a therapeutic target for breast cancer.