Maternal blood mitochondrial DNA content during normal and intrauterine growth restricted (IUGR) pregnancy
Maternal blood mitochondrial DNA content during normal and intrauterine growth restricted (IUGR) pregnancy
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DOI：
10.1016/j.ajog.2010.05.027
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发表时间：
2010-10-01
影响因子：
9.8
通讯作者：
Cetin, Irene
中科院分区：
文献类型：
--
作者：
Colleoni, Francesca;Lattuada, Debora;Cetin, Irene
OBJECTIVE: We investigated mitochondrial DNA (mtDNA) content in the maternal circulation of normal pregnancies of different gestational ages and in pregnancies complicated by intrauterine growth restriction (IUGR).STUDY DESIGN: We examined 70 maternal blood samples: 13 nonpregnant women; 45 normal pregnancies, divided into the 3 trimesters; and 12 pregnancies complicated by IUGR. MtDNA content was determined by real-time quantitative polymerase chain reaction, using a genomic control and a target gene.RESULTS: A highly significant progressive reduction in circulating mtDNA was observed in pregnant women of first, second, and third tri-mesters and compared to nonpregnant women (mean value: 237, 188, 144, and 283, respectively; P < .001). Moreover, mtDNA was significantly increased in women carrying IUGR fetuses compared to women with normal pregnancies (430 vs 144; P < .001).CONCLUSION: MtDNA could provide new insight into the mechanisms that occur during physiological gestation. Furthermore, mtDNA content may help recognize the IUGR disease in pregnancy.
