Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency
Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency
复制标题
DOI：
10.1097/ico.0000000000001820
复制
发表时间：
2019-03-01
期刊：
影响因子：
2.8
通讯作者：
Attico, Eustachio
中科院分区：
文献类型：
--
作者：
Deng, Sophie X.;Borderie, Vincent;Attico, Eustachio
目的：尽管在过去30年中对角膜缘干细胞缺乏症(LSCD)有了广泛的认识，但该疾病的定义并不明确，在这一领域的治疗医生和研究科学家之间也缺乏对诊断标准、分期和分类系统的一致意见。因此，在LSCD的定义、分类、诊断和分期方面取得全球共识的需求尚未得到满足。方法：角膜学会于2012年首次成立了角膜缘干细胞工作组。工作组分为几个小组委员会。此后，经过四次面对面的会议、频繁的电子邮件讨论和电话会议，经过全面的文献搜索，所有与会者就战略计划和方法达成一致，并就LSCD的定义、分类、诊断和分期达成了最终协议。目前的手稿已被广泛修改，以反映工作组的共识。结果：对LSCD的定义、分类、诊断和分期达成了共识。明确了LSCD的临床表现和诊断标准，建立了基于临床表现的LSCD分期系统。结论：这一全球共识为LSCD的定义、分类、诊断和分期提供了一个全面的框架。新建立的标准将有助于对LSCD的不同阶段进行正确的诊断和制定适当的治疗方案，这将有助于更好地了解LSCD的病情，并有助于这一领域的临床管理、研究和临床试验。
Purpose: Despite extensive knowledge gained over the last 3 decades regarding limbal stem cell deficiency (LSCD), the disease is not clearly defined, and there is lack of agreement on the diagnostic criteria, staging, and classification system among treating physicians and research scientists working on this field. There is therefore an unmet need to obtain global consensus on the definition, classification, diagnosis, and staging of LSCD.Methods: A Limbal Stem Cell Working Group was first established by The Cornea Society in 2012. The Working Group was divided into subcommittees. Four face-to-face meetings, frequent email discussions, and teleconferences were conducted since then to obtain agreement on a strategic plan and methodology from all participants after a comprehensive literature search, and final agreement was reached on the definition, classification, diagnosis, and staging of LSCD. A writing group was formed to draft the current manuscript, which has been extensively revised to reflect the consensus of the Working Group.Results: A consensus was reached on the definition, classification, diagnosis, and staging of LSCD. The clinical presentation and diagnostic criteria of LSCD were clarified, and a staging system of LSCD based on clinical presentation was established.Conclusions: This global consensus provides a comprehensive framework for the definition, classification, diagnosis, and staging of LSCD. The newly established criteria will aid in the correct diagnosis and formulation of an appropriate treatment for different stages of LSCD, which will facilitate a better understanding of the condition and help with clinical management, research, and clinical trials in this area.