The effect of ethanol and acetaldehyde on DNA synthesis in growing cells and on fetal development in the rat.
The effect of ethanol and acetaldehyde on DNA synthesis in growing cells and on fetal development in the rat.
复制标题
乙醇和乙醛对生长细胞 DNA 合成和大鼠胎儿发育的影响。
DOI：
10.1111/j.1530-0277.1981.tb04916.x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
B. Hetzel
中科院分区：
文献类型：
--
作者：
I. Dreosti;F. Ballard;G. Belling;I. Record;S. Manuel;B. Hetzel
在再生的大鼠肝脏、培养的大鼠细胞和大鼠胎儿组织中，乙醇和乙醛处理显著减少了3h -胸腺嘧啶与DNA的结合。胎儿中枢神经系统的掺入减少尤为明显，这两种化合物的掺入水平与据报道发生在人类酗酒者身上的水平相似。3h -胸腺嘧啶掺入胎儿DNA的减少，以及在怀孕期间用乙醛特异性处理的母鼠中观察到的胎儿死亡率增加，表明乙醛与胎儿酒精综合征相关的致畸机制有关。
Incorporation of 3H-thymidine into DNA was significantly diminished by treatment with ethanol and acetaldehyde in regenerating rat liver, rat cells in culture, and rat fetal tissues. Reduced incorporation was especially marked in the fetal central nervous system and was observed with both compounds at levels similar to those reported to occur in human alcoholics. The reduced incorporation of 3H-thymidine into fetal DNA, together with the increased fetal mortality observed in dams treated specifically with acetaldehyde during pregnancy, suggests that acetaldehyde is implicated in the mechanism of teratogenesis associated with the fetal alcohol syndrome.