Intralymphatic administration of liposome-encapsulated drugs to mice: possibility for suppression of the growth of tumor metastases in the lymph nodes.
Intralymphatic administration of liposome-encapsulated drugs to mice: possibility for suppression of the growth of tumor metastases in the lymph nodes.
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对小鼠进行脂质体封装药物的淋巴内给药：抑制淋巴结中肿瘤转移生长的可能性。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
V. Budker
中科院分区：
文献类型：
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作者：
V. Kaledin;N. Matienko;V. Nikolin;Y. V. Gruntenko;V. Budker
研究了两种药物顺二氨二氯铂（DDP）和氢化可的松（脂质体掺入或游离）的抗转移作用。实验模型为A型肝癌和肺腺癌局部和远处转移瘤，移植于A/He小鼠足垫。以磷脂酰胆碱为原料，采用超声分散法制备脂质体。顺铂和氢化可的松皮下注射到足底腱膜区的原发性肿瘤。认为该给药途径等同于淋巴内给药途径。有证据表明，只有脂质体掺入的DDP和氢化可的松显着降低肿瘤在区域淋巴结转移的频率和生长速度。观察到的效果不是由于药物对原发性肿瘤的直接作用。当未封装时，这些药物无效。脂质体包裹和游离DDP对肺腺癌远处转移无影响。淋巴管内给药脂质体包封的抗肿瘤药物被建议作为一种方法，用于预防性治疗淋巴结中的肿瘤转移。
The antimetastatic effects of two drugs, cis-diamminedichloroplatinum(II) (DDP) and hydrocortisone (liposome-incorporated or free), were studied. The experimental models were regional and distant metastases of hepatoma A and pulmonary adenocarcinoma, which were transplanted into the footpads of A/He mice. Liposomes were prepared from phosphatidylcholine by sonic dispersion. DDP and hydrocortisone were injected sc into the region of the plantar aponeurosis of the foot with the primary tumor. This administration route was considered to be equivalent to the intralymphatic route. Evidence indicated that only liposome-incorporated DDP and hydrocortisone decreased significantly the frequency and growth rate of tumor metastases in the regional lymph nodes. The effect observed was not due to the direct action of the drugs on the primary tumors. When nonencapsulated, these drugs were ineffective. Both liposome-encapsulated and free DDP did not affect distant metastases of pulmonary adenocarcinoma. The intralymphatic administration of liposome-encapsulated antitumor agents is suggested as a method for the prophylactic treatment of tumor metastases in the lymph nodes.