A new perspective on oxidation of DNA repair proteins and cancer
A new perspective on oxidation of DNA repair proteins and cancer
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DOI：
10.1016/j.dnarep.2019.02.006
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发表时间：
2019-04-01
期刊：
影响因子：
3.8
通讯作者：
Sweasy, Joann B.
中科院分区：
文献类型：
--
作者：
Alnajjar, Khadijeh S.;Sweasy, Joann B.
活性氧和氮物质（RONS）作为许多内源性细胞过程的副产物，响应于感染和暴露于各种环境因素而形成。RONS的增加可使抗氧化系统饱和并导致氧化应激。因此，大分子是氧化修饰的目标，包括DNA和蛋白质。DNA的氧化导致碱基修饰和沿着形成具有单链和双链断裂的脱碱基位点，已经被广泛研究。蛋白质氧化经常被忽视，直到最近才被认为是各种DNA修复蛋白的重要调控机制。本文综述了近年来蛋白质氧化调控DNA修复的研究进展，重点介绍了炎症与癌症的关系。
Reactive oxygen and nitrogen species (RONS) are formed as byproducts of many endogenous cellular processes, in response to infections, and upon exposure to various environmental factors. An increase in RONS cart saturate the antioxidation system and leads to oxidative stress. Consequently, macromolecules are targeted for oxidative modifications, including DNA and protein. The oxidation of DNA, which leads to base modification and formation of abasic sites along with single and double strand breaks, has been extensively investigated. Protein oxidation is often neglected and is only recently being recognized as an important regulatory mechanism of various DNA repair proteins. This is a review of the current state of research on the regulation of DNA repair by protein oxidation with emphasis on the correlation between inflammation and cancer.