Direct action of 1,25-dihydroxyvitamin D on bone: VDRKO bone shows excessive bone formation in normal mineral condition
Direct action of 1,25-dihydroxyvitamin D on bone: VDRKO bone shows excessive bone formation in normal mineral condition
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DOI：
10.1016/j.jsbmb.2004.03.021
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发表时间：
2004-05-01
影响因子：
4.1
通讯作者：
Seino, Y
中科院分区：
文献类型：
--
作者：
Tanaka, H;Seino, Y
在本研究中，研究了维生素D在骨代谢中的直接作用。维生素D被认为是骨代谢的重要激素，但很少有证据表明维生素D积极参与这一过程。在这里，我们通过将维生素D受体无效突变小鼠（VDR-/-）的骨移植到野生型小鼠中来显示维生素D的直接作用。这个过程使我们能够研究在正常体液环境中没有VDR的骨的变化。出乎意料的是，移植到野生型小鼠的VDR-/-骨的体积和密度与对照（移植到野生型小鼠的野生型骨）相比显著增加。我们表明，维生素D在骨代谢中起着关键作用。(C)2004 Elsevier Ltd.保留所有权利。
In the present study, the direct role of Vitamin D in bone metabolism was investigated. Vitamin D has been suggested to be an important hormone for bone metabolism, but there has been little evidence that Vitamin D actively participates in this process. Here, we show the direct action of Vitamin D by transplanting the bone of the Vitamin D receptor null mutant mice (VDR-/-) to the wild-type mouse. This procedure allowed us to investigate the changes in the bone without VDR in the normal humoral environment. Unexpectedly, the volume and the density of the VDR-/- bone transplanted to the wild-type mouse were significantly increased compared with the control (wild-type bone transplanted to the wild-type mouse). We show that Vitamin D has key roles in bone metabolism negatively. (C) 2004 Elsevier Ltd. All rights reserved.