FERTILE MALE-MICE WITH 3 SEX-CHROMOSOMES - EVIDENCE THAT INFERTILITY IN XYY MALE-MICE IS AN EFFECT OF 2 Y-CHROMOSOMES
FERTILE MALE-MICE WITH 3 SEX-CHROMOSOMES - EVIDENCE THAT INFERTILITY IN XYY MALE-MICE IS AN EFFECT OF 2 Y-CHROMOSOMES
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DOI：
10.1007/bf00360527
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发表时间：
1991-06-01
期刊：
影响因子：
1.6
通讯作者：
EICHER, EM
中科院分区：
文献类型：
--
作者：
HUNT, PA;EICHER, EM
在小鼠XYY雄性是不育的，可能是因为配对异常导致三个性染色体的存在导致减数分裂破裂。 我们已经培育出了雄性小鼠，命名为XYY*X，它有三个性染色体配对区域，但只有一个完整的Y染色体。 出乎意料的是，XYY*X雄性是可育的，尽管它们在性染色体配对方面并不比以前报道的XYY雄性更有效。 我们的结论是，不育的XYY男性是由两个Y染色体的有害影响的组合，大概作用前减数分裂，配对异常导致显着的减数分裂中断。
In the mouse XYY males are sterile, presumably because pairing abnormalities resulting from the presence of three sex chromosomes lead to meiotic breakdown. We have produced male mice, designated XYY*X, that have three sex chromosome pairing regions but only one intact Y chromosome. Unexpectedly XYY*X males are fertile, although they are no more efficient in sex chromosome pairing than previously reported XYY males. We conclude that the sterility of XYY males is caused by a combination of the deleterious effect of two Y chromosomes, presumably acting prior to meiosis, and pairing abnormalities resulting in significant meiotic disruption.