Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system.
Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system.
复制标题
急性烟草烟雾暴露通过交感神经系统加剧小鼠角膜伤口的炎症反应。
DOI：
10.1038/s42003-018-0270-9
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Li Zhijie
中科院分区：
文献类型：
--
作者：
Xiao Chengju;Wu Mingjuan;Liu Jun;Gu Jianqin;Jiao Xinwei;Lu Dingli;He Jingxin;Lin Cuipei;Xue Yunxia;Fu Ting;Wang Hanqing;Wang Guang;Yang Xuesong;Li Zhijie
暴露于烟草烟雾是一个主要的公共卫生问题，也可能影响眼科健康。基于以往的工作表明，在角膜伤口修复的交感神经系统（SNS）的重要作用，我们假设，急性烟草烟雾暴露（ATSE）可能通过SNS在角膜伤口修复的损害。我们发现ATSE能迅速增加正常角膜缘炎症反应的标志物。在磨损损伤后，ATSE加重炎症，损害伤口修复，并增强核因子-κB（NF-κB）和炎性分子如白细胞介素-6（IL-6）和IL-17的表达。我们发现化学SNS交感神经切除、局部肾上腺素能受体拮抗、NF-κ B1失活和IL-6/IL-17 A中和均能独立地减轻ATSE诱导的过度炎症反应并减轻其对愈合过程的损害。这些发现强调SNS可能代表ATSE诱导的炎症的主要分子传感器和介质。
Exposure to tobacco smoke is a major public health concern that can also affect ophthalmic health. Based on previous work demonstrating the important role of the sympathetic nervous system (SNS) in corneal wound repair, we postulated that acute tobacco smoke exposure (ATSE) may act through the SNS in the impairment of corneal wound repair. Here we find that ATSE rapidly increases the markers of inflammatory response in normal corneal limbi. After an abrasion injury, ATSE exaggerates inflammation, impairs wound repair, and enhances the expression of nuclear factor-κB (NF-κB) and inflammatory molecules such as interleukin-6 (IL-6) and IL-17. We find that chemical SNS sympathectomy, local adrenergic receptor antagonism,NF-κB1inactivation, and IL-6/IL-17A neutralization can all independently attenuate ATSE-induced excessive inflammatory responses and alleviate their impairment of the healing process. These findings highlight that the SNS may represent a major molecular sensor and mediator of ATSE-induced inflammation.